国际口腔医学杂志2017，Vol.44Issue(5)：519-522,4.DOI:10.7518/gjkq.2017.05.005
牙龈素促进牙龈卟啉单胞菌免疫逃逸的机制
Immune evasion strategies of Porphyromonas gingivalis via gingipains
摘要
Abstract
The keystone-pathogen hypothesis about the etiology ofperiodontitis has attracted the attention of scholars in recent years.In this view,Porphyromonas gingivalis is considered as a keystone pathogen in the pathogenic progression of periodontitis.Gingipains generated by Porphyromonas gingivalis are key virulence factors,which could assist Porphyromonas gingivalis to escape the killing effects of macrophages,neutrophils and complement system.The aim of this literature review is to discuss the immune evasion strategies of Porphyromonas gingivalis via gingipains.The exposition of this important mechanism may provide a further understanding of the pathogenic mechanism of gingipains,and lay a foundation for exploring new methods for the prevention and treatment of periodontitis.关键词
牙周炎/牙龈卟啉单胞菌/牙龈素/免疫逃逸Key words
periodontitis/Prophyromonas gingivalis/gingipain/immune evasion分类
医药卫生引用本文复制引用
李格格,潘佳慧,唐秋玲,刘歆婵,侯玉帛,于维先..牙龈素促进牙龈卟啉单胞菌免疫逃逸的机制[J].国际口腔医学杂志,2017,44(5):519-522,4.基金项目
吉林省科技厅自然科学基金项目(20150101076JC) （20150101076JC）
吉林省卫生技术创新项目(2016J073) （2016J073）
国家自然科学基金面上项目(81570983).This study was supported by Funding from the Jilin Provincial Science and Technology Department(20150101076JC),Jilin Provincial Technology Innovation Projects(2016J073) and National Natural Science Foundation of China(81570983). （81570983）
