基础医学与临床2017，Vol.37Issue(10)：1470-1473,4.
细胞焦亡在肾脏炎性损伤中的作用研究进展
Advance in the study of pyroptosis in renal inflammatory injury
摘要
Abstract
Pyroptosis is activated caspase-1 trigger special programmed cell. Recent studies have confirmed the py-roptosis in renal cells plays an important role. GSDMD cleavage caspase-1 regulating the downstream inflammatory cytokines maturation、release and triggering inflammation and pyroptosis. From renal inflammatory injury caused by NLRP3 activation, pyroptosis from GSDMD breakage, the review try to explain the NLRP3-caspase-1-GSDMD drived pyroptosis in renal inflammation injury to explore the essence of kidney inflammatory damage.关键词
肾脏炎性反应/细胞焦亡/NLRP3/caspase-1/GSDMDKey words
kidney inflammation/pyroptosis/NLRP3/caspase-1/GSDMD分类
医药卫生引用本文复制引用
吴燕升,高建东..细胞焦亡在肾脏炎性损伤中的作用研究进展[J].基础医学与临床,2017,37(10):1470-1473,4.基金项目
上海中医药大学中医学学科重点项目(上中医人字[2015]38号) （上中医人字[2015]38号）
上海中医药大学预算内项目(2015YSN40) （2015YSN40）
国家自然科学基金(81373613) （81373613）
上海市科委项目(1614090350030) （1614090350030）
