山西大学学报（自然科学版）2017，Vol.40Issue(3)：521-526,6.DOI:10.13451/j.cnki.shanxi.univ(nat.sci.).2017.03.016
季铵盐型共轭聚合物的制备及生物应用
Preparation and Biological Application of Conjugated Polymers with Quaternary Ammonium Salts
摘要
Abstract
A series of conjugated polymers with different lengths of side chains were designed and synthesized.These conjugated polymers were composed of benzothiadiazole,benzene fluorene groups in the backbones,and alkyl quaternary ammonium salts with different alkyl length in the side chain,respectively.The introduction of quaternary ammonium salts not only may improve the solubility of conjugated polymers in water,but also can bind and further kill tumor cells.The killing effects of these conjugated polymers to tumor cells were investigated by MTT method.The results showed that the kill efficiency gradually increased with the length of alkyl side chain.The research work provides an elementary theoretical basis for the preparation of biocomposite nanoparticles and the application in tissue and in vivo experiments.关键词
共轭聚合物/季铵盐/制备/生物应用Key words
conjugated polymer/quaternary ammonium salts/preparation/biological application分类
化学化工引用本文复制引用
冯丽恒,张飞..季铵盐型共轭聚合物的制备及生物应用[J].山西大学学报（自然科学版）,2017,40(3):521-526,6.基金项目
国家自然科学基金(21571116 （）
21371110 （）
21601111) （）
山西省优秀青年基金(201601D021054 （）
2014021006) （）
山西省中青年拔尖人才基金(2017) （2017）
