物理化学学报2017，Vol.33Issue(8)：1573-1588,16.DOI:10.3866/PKU.WHXB201704284
用于检测生物体系中线粒体活性氧的荧光探针
Fluorescent Probes for Mitochondrial Reactive Oxygen Species in Biological Systems
摘要
Abstract
In addition to being the energy powerhouse of the cell,mitochondria are an important source of reactive oxygen species (ROS) during the process of molecular oxygen metabolism.Mitochondrial ROS are closely associated with normal physiological functions as well as human diseases,and participate in cell signaling,nucleic acid and protein damage,and oxidative stress induction.However,the complicated interplay between mitochondrial ROS and the cellular pathological state has not been fully elucidated.It is expected that research on the mitochondrial ROS undertaking in the molecular pathogenesis of human diseases would benefit from development of efficient tools for the detection of these ROS.In recent years,an increasing number of fluorescent probes for mitochondrial ROS with high sensitivity and selectivity have been developed.Here,we present a review of the recent advances in small molecular fluorescent probes for selective detection of ROS inside the mitochondria.In this review,the design,synthesis,characteristics,and applications of the published fluorescent probes for mitochondrial ROS are discussed in detail.关键词
荧光探针/线粒体/活性氧/小分子/活细胞Key words
Fluorescent probe/Mitochondria/Reactive oxygen species/Small molecule/Living cells分类
化学化工引用本文复制引用
楼张蓉,李鹏,韩克利..用于检测生物体系中线粒体活性氧的荧光探针[J].物理化学学报,2017,33(8):1573-1588,16.基金项目
The project was supported by the National Natural Science Foundation of China (21503224,21673237).国家自然科学基金(21503224,21673237)资助项目 （21503224,21673237）
