畜牧兽医学报2017，Vol.48Issue(1)：1-7,7.DOI:10.11843/j.issn.0366-6964.2017.01.001
非编码RNA在胚胎发育过程中的作用
The Progress of Recent Advances in the ncRNA-Mediated Regulation during Embryogenesis
摘要
Abstract
Embryogenesis was a complex progress which is regulated by many transcriptional regulation factors.With the development of high-throughput sequencing technology,non-coding RNAs (ncRNAs) are found to play an important role in the embryogenesis,X chromosome inac tivation,gender regulation and the development of animal brain.Firstly,miRNAs regulate the expression of genes related to embryogenesis through targeting the 3'UTR of the targeted mRNAs.Secondly,lncRNAs mediate mammal X chromosome inactivation and insect X chromosome dosage compensation through interfering transcription or modifying chromatin.Thirdly,piRNAs can maintain the DNA integrity of the germ cell in the way of silencing transposon and regulating silkworm sex differentiation.Lastly,circRNAs can act as the spongy of miRNAs and play a great role in the development of mammal animal brain.Here,we elucidate the advances of ncRNAs through the regulation during animal embryogenesis,which will provide a reference for further study on the mechanism of ncRNA during the embryogenesis.关键词
非编码RNA(ncRNA)/胚胎发育/X染色体失活/性别调控/脑部发育Key words
ncRNA/embryogenesis/X chromosome inactivation/gender regulation/the development of brain分类
农业科技引用本文复制引用
吴昊,张运海,凌英会..非编码RNA在胚胎发育过程中的作用[J].畜牧兽医学报,2017,48(1):1-7,7.基金项目
国家自然科学基金项目(31301934 （）
31372310) （）
安徽省现代农业产业技术体系(2016-2020) （2016-2020）
