畜牧兽医学报2017，Vol.48Issue(9)：1565-1571,7.DOI:10.11843/j.issn.0366-6964.2017.09.001
GCN2和mTORC1信号路径对动物机体氨基酸平衡的调节作用
Regulation of GCN2 and mTORC1 Signaling Pathways on Amino Acid Balance in Animal Body
摘要
Abstract
Amino acid (AA) balance is of importance to the health and growth of mammals,and GCN2 and mTORC1 signaling pathways play crucial roles in maintaining AA balance in body.GCN2 signaling pathway can effectively sense intracellular AA starvation,mTORC1 signaling pathway can respond to the change of extracellular AA level.Combining with the recent studies regarding GCN2 and mTORC1,this review summarized characteristics of the GCN2 and mTORC1 signaling pathways and the related response mechanism under the condition of AA starvation and sufficiency,e.g.protein synthesis,refusing to feed,an increase of AA transporter,AA synthase expressions and autophagy initiation,etc..Understanding the regulatory mechanism by which cellular AA balance is kept under different AA nutrition status contributes to the nutritional regulating of nitrogen for animals,thus improving animal gut health.关键词
氨基酸平衡/信号途径/GCN2/mTORC1Key words
amino acid balance/signaling pathway/GCN2/mTORC1分类
农业科技引用本文复制引用
申俊华,朱伟云..GCN2和mTORC1信号路径对动物机体氨基酸平衡的调节作用[J].畜牧兽医学报,2017,48(9):1565-1571,7.基金项目
国家自然科学基金(31430082) （31430082）
国家重点基础研究发展计划项目(973项目)(2013CB127300) （973项目）
江苏省自然科学基金(BK20130058) （BK20130058）
