中国现代医学杂志2017，Vol.27Issue(20)：1-5,5.DOI:10.3969/j.issn.1005-8982.2017.20.001
二甲双胍对糖尿病大鼠肾脏的保护作用及其机制研究
Protective effect of Metformin on Streptozotocin-induced nephropathy in diabetic rats
梅艳 1欧三桃1
作者信息
- 1. 西南医科大学附属医院肾内科,四川泸州646000
- 折叠
摘要
Abstract
Objective To observe the effect of Metformin on diabetic nephropathy induced by Streptozotoein in rats,and to explore its preventive and therapeutic effect on diabetic nephropathy.Methods Thirty-six healthy male 14-week-old Wistar rats were randomly divided into three groups,i.e.normal control group,diabetic group and Metformin intervention group.Streptozotocin was used to induce diabetic rat model.TNF-α,IL-1β,IL-6 and anti-inflammatory cytokine IL-10 in the renal tissues were detected by Western blot.Results The levels of TNF-α,IL-6 and IL-1β in the renal tissues of the diabetic rats were significantly higher than those in the normal controls,while the IL-10 level was significantly lower than that in the control group (P＜0.05).After treatment with Metformin,the levels of TNF-c,IL-6 and IL-1β in the renal tissues decreased while the IL-10 level increased in the diabetic rats (P＜ 0.05).Conclusions Metformin can ameliorate diabetic nephropathy induced by Streptozotocin in rats by inhibiting the expression of inflammatory cytokines.关键词
二甲双胍/糖尿病/肾病/炎症细胞因子Key words
Metformin/diabetes/nephropathy/inflammatory cytokine分类
医药卫生引用本文复制引用
梅艳,欧三桃..二甲双胍对糖尿病大鼠肾脏的保护作用及其机制研究[J].中国现代医学杂志,2017,27(20):1-5,5.
