中国现代医学杂志2017，Vol.27Issue(20)：40-45,6.DOI:10.3969/j.issn.1005-8982.2017.20.008
KLF9在上皮性卵巢癌组织中的表达及其临床意义
Expression and clinical significance of KLF9 in patients with epithelial ovarian carcinoma
冯晓燕 1何琳 2孙志茹3
作者信息
- 1. 河北省保定市第二医院核医学科,河北保定071051
- 2. 河北省保定市第二医院妇产科,河北保定071051
- 3. 河北省定兴县云峰妇产医院妇产科,河北定兴072650
- 折叠
摘要
Abstract
Objective To investigate the expression of Krüppel-like transcription factor 9 (KLF9) in epithelial ovarian carcinoma and its clinical significance.Methods Sixty-three formalin-fixed paraffinembedded samples from epithelial ovarian carcinoma patients with 5-year follow-up and detailed clinicopathological information were selected.The expressions of KLF9 mRNA and protein were detected by qRT-PCR and immunohistochemistry respectively.The relationships of KLF9 with the clinicopathological factors and the prognosis were analyzed.Results The expression of KLF9 mRNA in the epithelial ovarian carcinoma tissues significantly decreased as compared with that in the normal ovarian tissues (P ＜ 0.05).Compared with the normal tissues,the tumor tissues showed a higher rate of KLF9 low-expression (P＜ 0.05).The low-expression of KLF9 was associated with TNM stage,lymph node metastases and ascetic fluid (P＜0.05).The overall survival of the KLF9 mRNA high-expression group was 46.8 months (95％ Ch 26,83),which was significantly longer than 32.6 months (95％ CI:12,74) of the KLF9 mRNA low-expression group (P ＜ 0.05).In the cancer tissues,the overall survival of the KLF9-positive cell high-expression group was 50.2 months (95％ CI:32,84),which was significantly longer than 31.1 months (95％ CI:12,79) of the KLF9-positive cell low-expression group (P ＜ 0.05).Cox regression analysis showed that KLF9 mRNA and KLF9-positive cell low-expression were the poor prognostic markers for epithelial ovarian carcinoma [HR =2.64 (95％ CI:1.14,3.56),P=0.017;HR=3.01 (95％ CI:2.19,4.51),P=0.010].Conclusions The expression of KLF9 is down-regulated in epithelial ovarian carcinoma which is associated with poor prognosis,therefore,KLF9 may serve as a tumor suppressor in the development of epithelial ovarian carcinoma.关键词
KLF9/上皮性卵巢癌/预后/临床意义Key words
KLF9/epithelial ovarian carcinoma/prognosis/clinical significance分类
医药卫生引用本文复制引用
冯晓燕,何琳,孙志茹..KLF9在上皮性卵巢癌组织中的表达及其临床意义[J].中国现代医学杂志,2017,27(20):40-45,6.
