中国现代医学杂志2017，Vol.27Issue(20)：73-75,3.DOI:10.3969/j.issn.1005-8982.2017.20.015
那他霉素联合伊曲康唑治疗真菌性角膜炎的疗效分析
Efficacy of Natamycin eye drops and Itraconazole in treatment of fungal keratitis
摘要
Abstract
Objective To observe clinical efficacy of Natamycin eye drops combined with Itraconazole capsules in the treatment of fungal keratitis.Methods Ninety-two patients with fungal keratitis treated in our hospital from March 2014 to May 2016 were randomly divided into observation group (Natamycin eye drops and Itraconazole capsules) and control group (Natamycin eye drops).After 14 days of treatment,the clinical efficacy,fluorescein sodium staining of cornea before and after treatment,and the incidences of adverse reactions were recorded.Results The total effective rate was 86.96％ in the observation group which was significantly higher than 63.04％ in the control group (P ＜ 0.05).The positive rate of corneal staining was 13.04％ in the observation group,and 36.96％ in the control group,the difference was significant (P＜ 0.05).Conclusions For the patients with fungal keratitis,oral administration of Itraconazole capsules on the basis of Natamycin eye drops can improve clinical efficacy,while medication convenience and safety are guaranteed.It is worthy of clinical application.关键词
那他霉素滴眼液/伊曲康唑胶囊/真菌性角膜炎/临床疗效/角膜染色Key words
Natamycin eye drop/Itraconazole capsule/fungal keratitis/clinical efficacy/corneal staining分类
医药卫生引用本文复制引用
忻丹丽,沈降,潘飞..那他霉素联合伊曲康唑治疗真菌性角膜炎的疗效分析[J].中国现代医学杂志,2017,27(20):73-75,3.基金项目
2014年浙江省医药卫生一般研究计划项目(No:2014KYB131) （No:2014KYB131）
