中国现代医学杂志2017，Vol.27Issue(20)：109-112,4.DOI:10.3969/j.issn.1005-8982.2017.20.023
硫普罗宁对原发性肝癌患者血清MMP-9、VEGF及肝功能的影响
Effect of Tiopionin on serum MMP-9 and VEGF levels and liver function of primary liver cancer patients
袁洪 1马彦寿 1李焕祥 1保广鹤1
作者信息
- 1. 青海省人民医院介入放射科,青海西宁810000
- 折叠
摘要
Abstract
Objective To investigate the effect of Tiopionin on serum levels of matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF),and liver function of primary liver cancer patients.Methods Ninety patients of primary liver cancer meeting the including criteria were selected as research objects.According to random number table,these patients were randomly divided into two groups equally.All patients were treated by TACE.After TACE,the control group was treated with conventional treatment.Besides that,the observation group was treated with Tiopionin.Then,the short-term curative efficacy,liver function indexes and serum levels of MMP-9 and VEGF were compared.Results After treatment,the observation group had a short-term effective rate of 71.1％,which was not statistically different from 60.0％ of the control group (P ＞ 0.05).After treatment,the liver function indices including ALT,AST and TBIL in the observation group were statistically lower than those in the control group (P＜ 0.05).In comparison with control group,the observation group had statistically lower serum levels of MMP-9 and VEGF after treatment (P ＜0.05).Conclusions Tiopionin improves short-term effective rate and liver function,and reduces serum levels of MMP-9 and VEGF after TACE in patients with primary liver cancer.关键词
硫普罗宁/原发性肝癌/肝功能/基质金属蛋白酶-9/血管内皮生长因子Key words
Tiopionin/primary liver cancer/liver function/matrix metalloproteinase-9/vascular endothelial growth factor分类
医药卫生引用本文复制引用
袁洪,马彦寿,李焕祥,保广鹤..硫普罗宁对原发性肝癌患者血清MMP-9、VEGF及肝功能的影响[J].中国现代医学杂志,2017,27(20):109-112,4.
