吉林大学学报（医学版）2017，Vol.43Issue(5)：893-896,后插3,5.DOI:10.13481/j.1671-587x.20170507
痛风宁胶囊对小鼠高尿酸血症和肾脏功能的改善作用
Improvement effects of Tongfengning Capsule on hyperuricemia and renal function in mice
摘要
Abstract
Objective:To discuss the influence of Tongfengning Capsule (TFN) in the levels of uricacid (UC),creatinine (Cr) and urea nitrogen (BUN) in mouse serum and the activities of the xanthine oxidase (XOD),adenosine deaminase (ADA) activity in the liver homogenate of the mice with hyperuricemia,and to observe the improvement effect of TFN on the pathological changes of liver tissue and to clarify its mechanisms.Methods:The models of mouse hyperuricemia were induced by yeast extract with potassium oxonate.Seventy mice were divided into blank control group,model group,low (200 mg · kg 1),medium (400 mg · kg-1) and high (800 mg · kg-1) doses of TFN groups,allopurinol positive drug control group (50 mg · kg-1),Tongfengshu (TFS,600 mg · kg-1) positive drug control group (n=10).The levels of UC,Cr,BUN in serum and the activities of XOD,ADA in homoggenate were detected and the histopathological changes of the kidney tissue of the mice were measured with HE staining.Results:Compared with blank control group,the levels of serum UC,Cr and BUN ofthe mice in model group were significantlyincreased (P＜0.01),and the activities of XOD and ADA in liver tissue were also increased (P＜0.01).Compared with model group,the levels of serum UC,Cr and BUN of the mice in positive drug control groups and different doses of TFN groups were decreased (P＜0.01),and the activities of XOD and ADA in liver tissue were also decreased (P＜0.05),especially in high dose of TFN group.Compared with model group,the pathologic changes such as renal glomerulus atrophy,renal interstitial fibrosis and expansion of renal tubule of the mice in positive drug control groups and high dose of TFN group were improved to a certain extent.Conclusion:TFN has improvement effcet on the hyperuricemia in the mice and its mechanism is related to the inhibition of uricogenesis and the promotion of UC excretion.关键词
痛风宁胶囊/高尿酸血症/酵母膏/氧嗪酸钾盐Key words
Tongfengning Capsule/hyperuricemia/yeast extract/potassium oxonate分类
医药卫生引用本文复制引用
樊海瑞,赵岩,傅警龙,张海波,王德超,郜玉钢,张连学..痛风宁胶囊对小鼠高尿酸血症和肾脏功能的改善作用[J].吉林大学学报（医学版）,2017,43(5):893-896,后插3,5.基金项目
国家农业部公益性行业科研专项资助课题(201303111) （201303111）
吉林省科技厅科技发展计划项目资助课题(20150204049YY,20140204013YY,20140311050YY) （20150204049YY,20140204013YY,20140311050YY）
