吉林大学学报（医学版）2017，Vol.43Issue(5)：897-902,6.DOI:10.13481/j.1671-587x.20170508
红参中精氨酸双糖苷对小鼠的抗疲劳作用
Anti-fatigue effect of arginyl fructosyl glucose from red ginseng in mice
摘要
Abstract
Objective:To investigate the anti-fatigue phenomenon induced by forced swimming in the mice,and to explore the anti-fatigue effect of argininyl fructoyl glucose (AFG) from red ginseng in the mice and its mechanism.Methods:The AFG was extracted from red ginseng.The ICR mice were divided into blank control group,low dose of AFG group (100 mg · kg-1),middle dose of AFG group (200 mg · kg-1) and high dose of AFG group (400 mg · kg-1) (n=20).The mice mere given a forced swimming test after continuous gavage for 28 d.The weights,organ indexes,time of forced swimming,contents of lactic acid (LD),blood urea nitrogen (BUN),hepatic glycogen (Gly) and expressing levels of PGC-1α in gastrocnemius of the mice in various groups were detected.Results:Compared with blank control group,the weights and organ indexes of the mice in low,middle and high doses of AFG groups had no significant differences (P＞ 0.05).Compared with blank control group,the time of forced swimming,contents of Gly and expressing levels of PGC-1α of the mice in low,middle and high doses of AFG groups were significantly increased (P＜0.05 or P＜0.01) in a dose-dependent manner.Compared with blank control group,The contents of LD and BUN in serum of the mice in low,middle and high doses of AFG groups were significantly decreased (P＜0.01).Conclusion:AFG has anti-fatigue effect in mice,and its mechanism may be related to energy metabolism.关键词
红参/精氨酸双糖苷/力竭性游泳/实时荧光定量聚合酶链反应/免疫印迹法Key words
red ginseng/arginyl fructosyl glucose/exhaustive swimming training/real-time fluorescence quantitative polymerase chain reaction/Western blotting method分类
医药卫生引用本文复制引用
黄宝亮,丁传波,王佳奇,郑毅男,刘文丛,张晶,徐晓华..红参中精氨酸双糖苷对小鼠的抗疲劳作用[J].吉林大学学报（医学版）,2017,43(5):897-902,6.基金项目
吉林省科技厅科技发展计划项目资助课题(20150311050YY) （20150311050YY）
吉林省科技厅自然科学基金项目资助课题(20160101017JC) （20160101017JC）
吉林省教育厅“十三五”科学技术项目资助课题(吉教科合字[2015]第197号) （吉教科合字[2015]第197号）
