吉林大学学报（医学版）2017，Vol.43Issue(5)：903-909,后插3-后插4,9.DOI:10.13481/j.1671-587x.20170509
兔颞下颌关节突缺损模型的建立和CFR-PEEK材料人造关节的修复效果评价
Establishment of TMJ defect models and evaluation on repair effect of CFR-PEEK material artificial joint in rabbits
摘要
Abstract
Objective:To investigate the method of arthroplasty for reconstructing femporomandibular joint (TMJ) after the establishment of TMJ articular defect models in the rabbits,and to clarify the replacement and repair effects of carboh fiber reinforced polyetheretherketone (CFR-PEEK) material TMJ prostheses,and to provide an experimental basis for the clinical application of CFR-PEEK artificial joints to replace TMJ.Methods:Thirteen healthy adult Japanese rabbits were randomly divided into experimental group (n=6),positive control group (n=4) and negative control group (n =3).The right TMJ articular process of the rabbits in experimental group were resected to establish the joint defect models,and then the CFR-PEEK artificial joints were impanted.The right TMJ articular process of the rabbits in positive control group were resected,and the joint defect models were established without the CFR-PEEK artificial joint implantation.The rabbits in negative control group didn't receive any treatment.The body weights of the rabbits in each group were measured in 13 weeks.The effects of fixation and replacement after artificial joint implantation were assessed by CT imaging.Results:The TMJ articular process defect model was successfully implanted with the CFR-PEEK artificial joint.The CT imaging results after threedimensional reconstruction and CT images by contrast in vitro showed that the CFR-PEEK-implanted artificial joint was fixed well,it could be instead of the normal joint function.Compared with positive control group,the weights of rabbits in experimental group were significantly increased (P＜ 0.05) at 13 weeks;compared with positive control group,the weights of rabbits in experimental group and negative control group were both significantly increased (P＞0.05) at 13 weeks,but there was no significant difference between them (P＞0.05).The weights of rabbits in experimental group and negative control group kept normal growth;the weights of rabbits in positive control group was increased slowly,and even stopped growing or was negative.Conclusion:The CFR-PEEK artificial joint can be successfully implanted into the TMJ defect model and be used to repair the defect which help to restore chewing function.The CFR-PEEK is expected to be an ideal material for reconstructing TMJ.关键词
颞下颌关节/缺损/碳纤维增强型聚醚醚酮材料/人造关节Key words
temporomandibular joints/defection/carbon fiber reinforced polyetheretherketone/artificial joints分类
医药卫生引用本文复制引用
韩明林,李明贺,及昕,韩茹钰,张宁,崔磊华,孙兰芳,韩成敏..兔颞下颌关节突缺损模型的建立和CFR-PEEK材料人造关节的修复效果评价[J].吉林大学学报（医学版）,2017,43(5):903-909,后插3-后插4,9.基金项目
吉林省科技厅自然科学基金资助课题(3D515V663431) （3D515V663431）
吉林省卫计委青年科研基金资助课题(3D514CP23431) （3D514CP23431）
