成都中医药大学学报2017，Vol.40Issue(3)：4-6,102,4.DOI:10.13593/j.cnki.51-1501/r.2017.03.004
湿阻中焦证对葡萄糖代谢糖异生途径的影响及藿香正气散干预后的变化
Change of Syndrome of Dampness in Middle Jiao Effect on Glucose Metabolism and Gluconeogenesis and Huoxiangzhengqi Powder Intervention
摘要
Abstract
Objective:Research of Huoxiangzhengqi powder intervention on syndrome of dampness in middle Jiao model effects on metabolism glucose and gluconeogenesis mechanism to reveal the effects of syndrome of dampness in middle Jiao model on glucose metabolism in the gluconeogenic pathway,revealed in the regulation of energy metabolism and the spleen and stomach Huoxiangzhengqi powder in the treatment of syndrome of dampness in middle Jiao of the scientific connotation from the level of system biology.Methods:The natural model and comprehensive model combined with the three main factors of establishing simulation of dampness,syndrome of dampness in middle Jiao model.Measure the content of pyruvate pyruvate carboxylase and glucose by biochemical method;measure the content of pyruvic acid and glucose-6-phosphatase by enzyme-linked immunosorbent assay.Results:The content of syndrome of dampness in middle Jiao model of pyruvic acid reduce,pyruvate carboxylase,glucose-6-phosphatase are reduce and glucose content increased;Huoxiangzhengqi powder can enhance the glucose metabolism of gluconeogenesis.Conclusion:Thesyndrome of dampness in middle Jiao will lead to increased energy consumptionrather than the body's absorption and use of glucose lead to inadequate energy supply,which may be one of the pathological basis of syndrome of dampness in middle Jiao of lassitude,anorexia,diet reduction;Huoxiangzhengqi powder could strengthen the effect of syndrome of dampness in middle Jiao energizer gluconeogenesis and glucose some of the decomposition and transformation,which may be Huoxiangzhengqi powder treatment of rheumatism,a mechanism of action to alleviate the lassitude,anorexia and other symptoms of diet reduction.关键词
湿阻中焦证/糖异生/藿香正气散Key words
Syndrome of dampness in middle Jiao/Gluconeogenesis/Huoxiangzhengqi powder分类
医药卫生引用本文复制引用
张凯文,黄秀深,陈芳,杨旭,王琦越,于毅..湿阻中焦证对葡萄糖代谢糖异生途径的影响及藿香正气散干预后的变化[J].成都中医药大学学报,2017,40(3):4-6,102,4.基金项目
国家自然科学基金资助项目(81373544) （81373544）
