南方医科大学学报2017，Vol.37Issue(10)：1308-1314,7.DOI:10.3969/j.issn.1673-4254.2017.10.05
中性粒细胞/淋巴细胞比率预测慢性阻塞性肺疾病患者并发2型糖尿病的价值:前瞻性队列研究
Neutrophil-to-lymphocyte ratio as a predictor for type 2 diabetes mellitus in patients with chronic obstructive pulmonary disease:a cohort study of 404 cases
摘要
Abstract
Objective To assess the value of neutrophil-to-lymphocyte ratio (NLR) for predicting type 2 diabetes mellitus (T2DM) in patients with chronic obstructive pulmonary disease (COPD). Methods A cohort of 404 non-diabetic patients diagnosed with stable COPD between January,2010 and December,2012 at Zhujiang Hospital were enrolled and followed up for 3 years,during which fast blood glucose(FBG)was monitored every 6 months.The primary endpoint was the occurrence of T2DM,and the cumulative incidence of T2DM in this cohort was calculated.The patients who developed T2DM and those without T2DM at the end of the follow-up were compared for clinical parameters to identify the potential predictors for T2DM in patients with stable COPD. Results After follow-up for a mean of 2.1 years, 41 (10.1%) patients with COPD developed T2DM, who showed significantly higher baseline NLR levels than those without T2DM (P<0.001). The receiver-operating characteristic(ROC)analysis revealed that the optimum cut-off value for NLR was 5.626.Spearman rank correlation analysis suggested that the incidence of T2DM in the patients was positively correlated with the number of hospital admissions for acute exacerbation of COPD in the past year (r=0.136, P=0.006), hypertension (r=0.151, P=0.002) and NLR (r=0.340, P<0.001). Logistic regression analysis identified triglyceride(TG)(P=0.047)and NLR(P<0.001)as the independent risk factors for T2DM in patients with COPD. Conclusion The occurrence of T2DM in COPD patients is closely related to NLR level, which may serve as an early predictor for T2DM in these patients.关键词
慢性阻塞性肺疾病/中性粒细胞/淋巴细胞比率/2型糖尿病Key words
chronic obstructive pulmonary disease/neutrophil-to-lymphocyte ratio/type 2 diabetes mellitus引用本文复制引用
叶涛,杨银,王凯,王梅,孙嘉,杜越,陈新..中性粒细胞/淋巴细胞比率预测慢性阻塞性肺疾病患者并发2型糖尿病的价值:前瞻性队列研究[J].南方医科大学学报,2017,37(10):1308-1314,7.基金项目
广东省医学科学技术研究基金项目(A2016399) （A2016399）
广州市科技计划项目(201507020033) （201507020033）
南方医科大学临床研究培育项目(LC2016PY032) （LC2016PY032）
