南方医科大学学报2017，Vol.37Issue(10)：1315-1321,7.DOI:10.3969/j.issn.1673-4254.2017.10.06
1h负荷血糖:评价阻塞性睡眠呼吸暂停患者血糖变化的更好指标?
One-hour post-load plasma glucose:a better indicator of glucose metabolism for obstructive sleep apnea?
摘要
Abstract
Objective To assess the value of blood glucose at different time points in oral glucose tolerance test (OGTT), particularly one-hour post load plasma glucose (1 hPG), in evaluating glucose metabolism in adult patients with obstructive sleep apnea (OSA). Methods Eighty-nine adultswith newly diagnosed OSA were analyzed retrospectively for sleep architecture assessed using polysomnography and glucose metabolism assessed by OGTT at different time points (0, 30, 60, 120,and 180 min).Pearson's correlatives and multiple linear regression models were established to investigate the correlations between glucose metabolism and other indices including sleep architecture, apnea hypopnea index (AHI), mean and lowest oxygen saturation(MSO2and LSO2)and obesity measurements.Results The majority(67.4%)of the patients had abnormal 1 hPG, and 41.6% had abnormal 2 hPG. 1 hPG was positively correlated with neck circumference (r=0.245), abdomen circumference (r=0.231), systolic blood pressure (r=0.213), diastolic blood pressure (r=0.276) and AHI (r=0.324), and was negatively associated with MSO2(r=-0.341)and LSO2(r=-0.387)(all P<0.05).After controlling for age,BMI,neck and abdomen circumferences,1 hPG was found to inversely correlated with MSO2(r=-0.253,P=0.032)and LSO2(r=-0.311,P=0.008).In non-obese OSA subgroup,1 hPG was significantly associated with OSA-related indices,and regression models showed that LSO2 and N2 were the two most important contributors to 1 hPG(adjusted R2=0.349,P<0.001);plasma glucose at other time points did not show such correlations. Conclusions 1 hPG abnormality occurs earlier than 2 hPG in OSA patients. 1 hPG is significantly associated with OSA independent of obesity and may serve as a better index for measuring OSA-related glucose disorder.关键词
阻塞性睡眠呼吸暂停/口服葡萄糖耐量试验/肥胖/1h负荷血糖Key words
obstructive sleep apnea/oral glucose tolerance test/obesity/one-hour post load plasma glucose引用本文复制引用
冯媛,郭东英,罗淼,许婷,李丹青,雷娅辉,李涛平..1h负荷血糖:评价阻塞性睡眠呼吸暂停患者血糖变化的更好指标?[J].南方医科大学学报,2017,37(10):1315-1321,7.基金项目
国家十二五科技支撑计划(2012BAI05B03) （2012BAI05B03）
广东省科技计划项目(面上项目2013) （面上项目2013）
南方医院院长基金(2013Z001) （2013Z001）
