南方医科大学学报2017，Vol.37Issue(10)：1410-1414,5.DOI:10.3969/j.issn.1673-4254.2017.10.22
磁共振扩散加权成像表观扩散系数与肿块型浸润性乳腺癌分子亚型的相关性
Correlations between apparent diffusion coefficient in diffusion-weighted magnetic resonance imaging and molecular subtypes of invasive breast cancer masses
尚柳彤 1杨家斐 1卢晶 1王婷婷 2周颖 3邢新博 1王鑫坤 1杨淑辉 1胡明艳1
作者信息
- 1. 解放军总医院第一附属医院 放射科,北京100047
- 2. 新疆医科大学公共卫生学院儿少卫生与妇幼保健学教研室,新疆 乌鲁木齐830000
- 3. 解放军总医院第一附属医院 病理科,北京100047
- 折叠
摘要
Abstract
Objective To study the correlation of apparent diffusion coefficient (ADC) measured by diffusion-weighted magnetic resonance imaging (MRI) with the molecular subtypes and biological prognostic factors of invasive breast cancer masses. Methods Breast MRI data (including dynamic enhanced and diffusion-weighted imaging) were collected from 64 patients with pathologically confirmed invasive breast cancer masses (a total of 69 lesions). The mean ADC values of the lesions were calculated and their correlations were analyzed with the 5 molecular subtypes of invasive breast cancer and the biological prognostic factors including estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor 2 (HER2), and Ki-67 index. Results The ADC values did not differ significantly among the 5 molecular subtypes of invasive breast cancer masses (P>0.05) or among lesions with different ER, PR, or HER2 status (P>0.05). The mean ADC values were significantly higher in Ki-67-positive lesions than in the negative lesions (P=0.023 and negatively correlated with the expressions of Ki-67(r=-0.249).Conclusion ADC value can not be used to identify the molecular subtypes of invasive breast cancer masses or to evaluate the biological prognosis of the lesions, but its correlation with Ki-67 expression may help in prognostic evaluation and guiding clinical therapy of the tumors.关键词
乳腺肿瘤/磁共振成像/表观扩散系数/预后因子Key words
breast neoplasms/magnetic resonance imaging/diffusion-weighted imaging/prognostic factors引用本文复制引用
尚柳彤,杨家斐,卢晶,王婷婷,周颖,邢新博,王鑫坤,杨淑辉,胡明艳..磁共振扩散加权成像表观扩散系数与肿块型浸润性乳腺癌分子亚型的相关性[J].南方医科大学学报,2017,37(10):1410-1414,5.
