中国实用神经疾病杂志2017，Vol.20Issue(15)：19-21,3.DOI:10.3969/j.issn.1673-5110.2017.15.006
不同药物对帕金森病患者血浆同型半胱氨酸的影响
Effects of different drug on plasma homocysteine in patients with Parkinson's disease
摘要
Abstract
Objective To investigate the effects of different drug regimens on plasma levels of homocysteine (Hcy),folic acid and vitamin B12 in patients with Parkinson's disease,and the relationship between the severity of PD and plasma Hcy level.Methods A total of 79 patients with PD were divided into four groups according to different methods (untreated group,taking drugs except dopamine group,only dopamine drug group and mixed group),the plasma level of Hcy in all groups were compared;We also observed the relationship between Hoehn-Yahr (H-Y) and plasma Hcy level,the relationship between plasma Hcy level and the course of PD,and compared the levels of folic acid and vitamin B12 in different treatment groups.Results The level of plasma Hcy in the dopamine group was significantly higher than that in the untreated group (P＜0.05).The level of plasma Hcy in the patients with longer disease duration was higher (P＜0.05).The levels of folic acid and vitamin B12 in the dopamine group were significantly lower than those in the untreated group (P＜0.05).Conclusion Dopamine can cause elevated plasma levels of Hcy,which may decrease the level of folic acid and vitamin B12,and then promote the progression of PD.The PD patients with high plasma level of Hcy may have a worse stage and longer duration.关键词
帕金森病/药物治疗/血浆同型半胱氨酸/叶酸/维生素B12Key words
Parkinson's disease/Drug treatment/Plasma homocysteine/Folic acid/Vitamin B12分类
医药卫生引用本文复制引用
江雯涵,袁磊,徐丹,闻瑛,杨进平,周海燕,杨磊,陈后勤,张蕊..不同药物对帕金森病患者血浆同型半胱氨酸的影响[J].中国实用神经疾病杂志,2017,20(15):19-21,3.基金项目
太仓市科技支撑(社会发展卫生医疗)计划项目(TC2014S11) （社会发展卫生医疗）
