华西口腔医学杂志2017，Vol.35Issue(5)：514-519,6.DOI:10.7518/hxkq.2017.05.014
白细胞介素-10基因型与墨玉县维吾尔族成人 慢性牙周炎易患性的相关性研究
Correlation between interleukin-10 polymorphisms and susceptibility to chronic periodontitis among Uygur adults in the Moyu area
摘要
Abstract
Objective This study aims to investigate the association between interleukin (IL)-10-597 (C/A) single-nucleotide polymorphisms and chronic periodontitis of Moyu Uygur population in Xinjiang Uygur Autonomous Region of China.Methods In accordance with the inclusion and exclusion criteria, the buccal swabs of 300 subjects were randomly selected from the epidemiological investigation of Uygur adults in Moyu county on April and May 2013. The study was conducted on a healthy control group, a mild chronic periodontitis group, and a moderate-to-severe chronic periodontitis group, with each comprising 100 samples. The IL-10-597(C/A) site in the promoter sequences was analyzed using the tetra-primer amplification refractory mutation system-polymerase chain reaction method to test the genotype and allele distributions. Statistical analysis was performed using Chi-squared test and ordinal classification Logistic regression analysis.Results The genotype and allele frequencies of the IL-10-597(C/A) site in the healthy control group, mild chronic periodontitis group, and moderate-to-severe chronic periodontitis group exhibited no significant difference (P>0.05). The age of all the samples was associated with chronic periodontitis. The risk of chronic periodontitis in the people of 55-65 years old was 25 times in the people under the age of 35 (OR=25.56,P<0.001).Conclusion The IL-10-597 (C/A) single-nucleotide polymorphisms in the gene promoter are not associated with chronic periodontitis in Uygur adult population.关键词
白细胞介素-10/慢性牙周炎/单核苷酸多态性Key words
interleukin-10/chronic periodontitis/single nucleotide polymorphisms分类
医药卫生引用本文复制引用
张雨慧,黄萍,林静,赵今..白细胞介素-10基因型与墨玉县维吾尔族成人 慢性牙周炎易患性的相关性研究[J].华西口腔医学杂志,2017,35(5):514-519,6.基金项目
新疆维吾尔自治区自然科学基金(2014211C065) Natural Science Foundation of Xinjiang Uygur Autonomous Region of China (2014211C065). （2014211C065）
