四川大学学报（医学版）2017，Vol.48Issue(5)：745-749,5.
双歧杆菌对中老年人健康影响的菌种特异性初探
A Preliminary Analysis of Bifidobacterial Species Dependent Influence on the Health of the Elderly
摘要
Abstract
Objective To analyze the species dependent effect of bifidobacteria to the heath of the middle and elderly.Methods Total 148 healthy volunteers living in Chengdu with 50-74 years old were recruited in 2015.The blood samples were collected from them and analyzed physiologically and immunologically.The fecal bifidobacterial were also analyzed by real-time fluorescence quantitative PCR (qPCR) using 16S rRNA targeting designed gene and species specific primers.Results Bifidobacterium can be detected in feces of the elderly,the detection rate was 100％,108/g fecal.Especially,more species predominated in the infants were found the tested subjects.Bifidobacterium was positively associated with urea nitrogen (r=0.214,P＜0.05).B.adolescentis was negatively associated with body mass index (BMI) (r=-0.311,P＜0.05),while B.catenulatum was positive to BMI (r=0.167,P＜0.05).B.breve and high density lipoprotein-cholesterol (HDL-C) were negatively correlated (r=-0.247,P＜0.05).Bifidobacterium infantis and HDL-C were positively correlated (r=0.350,P＜0.05).Among tested immune parameters,only B.bifidum was found to be positive associated with IgA (r=0.365,P＜0.05).Conclusion Bifidobacterium might affect the host physiologically and immunology in the species dependent manner.Keeping intestinal bifidobacteria in the ideal species composition might be one of effective ways to slow immune senescence,and promote the health of the elderly.关键词
中老年人/双歧杆菌/菌种特异性/免疫机能/生理代谢Key words
Elderly/Bifidobacterium/Species specificity/Immunity/Physiology引用本文复制引用
王舒悦,于晓红,李鸣,李珊珊,苗俊杰,余倩,何方..双歧杆菌对中老年人健康影响的菌种特异性初探[J].四川大学学报（医学版）,2017,48(5):745-749,5.基金项目
达能营养基金(No.14H0983)资助 （No.14H0983）
