江苏大学学报（医学版）2017，Vol.27Issue(5)：369-373,5.DOI:10.13312/j.issn.1671-7783.y170131
γ-氨基丁酸能神经元条件性敲除PGC-1α基因对小鼠焦虑抑郁行为的影响
Effects of PGC-1α gene knockout in the GABAnergic neurons on anxiety and depression in mice
摘要
Abstract
Objective:To test the effects of conditioned knockout of peroxisome proliferator-activated receptor-γ coactivator-1α(PGC-1α) gene in the GABAergic neuron on anxiety and depression in mice.Methods:The mice with conditioned knockout of PGC-1α gene in GABAnergic neurons were evaluated on the vertical open field and the elevated plus maze,as well as the tail suspension and forced swimming tasks.Results:The vertical open field and the elevated plus maze experiments showed that the homozygous mice were significantly hyperactive and less anxiety than the wild type ones (P ＜ 0.05);the tail suspension and forced swimming tests exhibited that the homozygous mice show significantly anti-depressive performance than the wild type ones(P ＜ 0.05).Conclusion:PGC-1α gene knockout in GABAnergic neurons might induce less-anxiety and anti-depression behavior in mice.关键词
γ-氨基丁酸神经元/PGC-1α/抗焦虑抑郁行为/动物行为学Key words
γ-amino-butyric-acid-(GABA)-nergic neurons/PGC-1α/anti-anxiety/anti-depression/animal behavioral tests分类
医药卫生引用本文复制引用
姜扬,卢俅,王珂欣,张维宁,王佳,李国海,冯驰,王玉聪,汪磊,恽琪,徐家丹,秦艳..γ-氨基丁酸能神经元条件性敲除PGC-1α基因对小鼠焦虑抑郁行为的影响[J].江苏大学学报（医学版）,2017,27(5):369-373,5.基金项目
国家自然科学基金资助项目(81671053) （81671053）
江苏省临床医学专项(BL2014068,BE2016724) （BL2014068,BE2016724）
江苏大学高级人才科研启动项目(13JDG001,11JDG112) （13JDG001,11JDG112）
