江苏大学学报（医学版）2017，Vol.27Issue(5)：420-422,427,4.DOI:10.13312/j.issn.1671-7783.y160210
精神分裂症患者外周血白细胞miR-198、miR-206的表达及意义
Expression and significance of peripheral blood leucocyte miR-198 and miR-206 in schizophrenics
摘要
Abstract
Objective:To evaluate the differences of peripheral blood leucocyte MicroRNA-198 (miR-198) and MicroRNA-206(miR-206) levels between schizophrenics and healthy control.Methods:A total of 40 cases of schizophrenics were chosen as case group and 40 healthy people matched with gender and age were selected as control group.The relative expression levels (ΔCt) of peripheral blood leucocyte miR-198 and miR-206 were measured by real time PCR.Symtomatology of schizophrenics was evaluated by Positive And Negative Syndrome Scale (PANSS).Results:The ΔCt of miR-198 and miR-206 (t =20.363,P ＜0.01;t =33.762,P ＜0.01) were higher in the schizophrenics,compared with the healthy control.There were no linear correlation between the relative expression of miR-198 or miR-206 and PANSS(P ＞ 0.05).Conclusion:The level of peripheral blood leucocyte miR-198 and miR-206 may be useful for diagnosis and prognosis in schizophrenics.关键词
精神分裂症/miR-198/miR-206Key words
schizophrenia/miR-198/miR-206分类
医药卫生引用本文复制引用
曲洪芳,朱云程,王芳,周军,张尉,常宪鲁,李国海..精神分裂症患者外周血白细胞miR-198、miR-206的表达及意义[J].江苏大学学报（医学版）,2017,27(5):420-422,427,4.基金项目
镇江市社会发展项目(SH2012058) （SH2012058）
