四川中医2017，Vol.35Issue(8)：54-56,3.
膝骨性关节炎患者NO及TGF-β1与中医证型相关性临床研究
Clinical Study on Relativity of NO and TGF-Beta 1 Between Traditional Chinese Medicine Syndromes in Patients with Knee Osteoarthritis
摘要
Abstract
Objective:To investigate the clinical manifestation of TCM syndromes of knee osteoarthritis and the relationship between NO and TGF-β1.Methods:Sixty patients with knee osteoarthritis selected in our hospital,30patients of marrow deficiency of kidney deficiency type were selected as experiment group 1,and 30patients of stagnation of blood stasis type were selected as experimental study2,and then 30patients were diagnosed as healthy,as the controlled group of this experiment,as the third group.The blood of all cases in the experimental group and the controlled group was extracted and tested.In the experimental group,two groups of patients with the experiment group 1 and the experiment group 2were treated for half a month respectively.The levels of nitric oxide and transforming growth factor-β1were measured before and after treatment.The controlled group (group 3) was directly collected for the detection of nitric oxide and growth factor-β1.Results:Before treatment,the levels of nitric oxide in the blood of the two groups was much higher than that of the controlled group,the levels of transforming growth factor-β1 in the blood of the two groups were significantly lower than the controlled group (group 3),and the content of transforming growth factor-β1in the blood of patients with deficiency of the experiment group 1was higher than that of the experiment group 2.The difference was statistically significant P＜0.05.After treatment,the NO content in the experimental group was decreased,and the content of the kidney in the blood group was lower than that in the patients with the experiment group 2.The level of transforming growth factor-beta 1 was increased,and the content of blood in the experimental group 1 was higher than that of the experimental group 2,the difference was statistically significant,P＜0.05.Conclusion:Knee osteoarthritis syndrome and transforming growth factor-β1 and nitric oxide have a certain correlation.关键词
关节炎/中医证型/一氧化氮/生长因子Key words
Arthritis/TCM syndrome/Nitric oxide/Growth factor分类
医药卫生引用本文复制引用
彭海,谢相志,刘金成,李进选..膝骨性关节炎患者NO及TGF-β1与中医证型相关性临床研究[J].四川中医,2017,35(8):54-56,3.基金项目
北京市大兴区科学技术科研课题(编号:14060-2) （编号:14060-2）
