生殖医学杂志2017，Vol.26Issue(10)：1006-1010,5.DOI:10.3969/j.issn.1004-3845.2017.10.010
血生物指标在宫颈慢性炎症及其病变中的作用分析研究
Role of blood biochemical indexin cervical chronic inflammation and lesions
摘要
Abstract
Objective:To study the changes of blood biochemical index in the patients infected by human papillomavirus(HPV)for obtaining scientific evidences in support of prevention and treatment for cervical inflammation and lesions.Methods:The data including the results of blood routine examination,serum trace element content detection and colposcopic pathology of 233 patients diagnosed with high-risk HPV infection in the Liuzhou Maternity and Child Health Care Hospital from May to December 2016 were collected.According to colposcopy and pathological results,the patients were divided into five groups:chronic inflammatory(HPV infection alone),CINⅠ,CINⅡ,CINⅢ,and cervical cancer group.Meanwhile,233 patients with negative HPV test were included as the control group.The variance analysis and LSD multiple comparison were used to analyze the differences among the different groups.Results:The differences in various blood parameters including RBC and WBC were not significantly differnt among the six groups(P＞0.05).Compared with control group,the mean platelet volume(MPV) and mean hemoglobin concentration(MCHC)were significantly decreased(P＜0.05),but the platelet count (PLT),platelet count(PCT)and blood cell mean volume(MCV)were significantly increased in the chronic inflammatory group(P＜0.05).The PLT and PCT were significantly increased,but MPV was significantly decreased in CIN Ⅰ group(P＜0.05).The MCHC and MPV were significantly decreased,but PLT & PCT were significantly increased in CINⅡ and CINⅢ group(P＜0.05).The levels of MCV,MPV,PLT and PCT were significantly increased,but the MCHC was significantly decreased in the cervical cancer group(P＜ 0.05).There were no significant differences in the average levels of Zn,Mg and Cu among the six groups (P＞0.05).Compared with the control group,the levels of serum calcium(Ca)and iron (Fe)were significantly decreased in chronic inflammation group(P＜0.05).The levels of serum Fe were significantly decreased in CIN Ⅰ,CINⅡ,CINⅢ group and cervical cancer group(P ＜0.05).Conclusions:The degree of cervical intraepithelial lesion may be related to MPV,MCV,MCHC,PLT,PCT and serum trace elements in patients with HPV infection,but need to further expand the sample size of study.关键词
宫颈病变/HPV感染/血液检查/微量元素Key words
Cervical lesions/HPV infection/Blood routine examination/Trace elements引用本文复制引用
陶华,韦燕珍,王兴民,周红敏,麦美云..血生物指标在宫颈慢性炎症及其病变中的作用分析研究[J].生殖医学杂志,2017,26(10):1006-1010,5.基金项目
广西医药卫生科研课题(Z2016536) （Z2016536）
