生殖医学杂志2017，Vol.26Issue(10)：1028-1034,7.DOI:10.3969/j.issn.1004-3845.2017.10.014
辅酶Q10联合维生素E对高龄女性卵巢功能及IVF结局的影响
Effect of co-enzyme Q10 combined with vitamin E on ovary reserve and IVF outcome in women with advanced age
摘要
Abstract
Objective:To investigate effect of co-enzyme Q10 combined with vitamin E on ovary reserve and IVF outcome of women with advanced age.Methods:A total of 152 cycles of the women with advanced age were randomly divided into three groups:group A as control(n=46),group B as supplementation of vitamin E only(n=53),and group C as supplementation of co-enzyme Q10 combined with vitamin E(n=53).Furthermore,the patients were subdivided into two groups:the patients aged between 35 to 40 years in group1 (A1/B1/C1)and the patients aged over 40 years in group 2 (A2/B2/C2).The ovarian reserve index,ovarian response and IVF outcome were compared among the groups.Results:(1)For patients aged between 35 to 40 years:there were significant increases in antral follicle count(AFC)and significant decreases in basic levels of FSH and E2 in group C1 as compared with group A1 and B1(P＜0.05).There was a significant decrease in basic FSH(P＜0.05),but no difference in AFC(P＞ 0.05)in group B1 as compared with group A1.No matter compared with group A1 or B1,there were significant decreases in the dosage and days of Gn used,while significant increases in endometrium thickness on the HCG day,E2 peak level,number of oocytes retrieved in group C1(P＜0.05).There was no significant difference in the above indexes between A1 and B1 (P＞0.05).(2)For patients aged over 40 years:there were significant increase in AFC and significant decreases in basic levels of FSH and E2 in group C2 as compared with group A2 and B2(P＜0.05).There was no significant differences in basic levels of FSH & E2 and AFC between group B2 and group A2(P＞0.05).No matter compared with group A2 or B2,there were significant decreases in the dosage and days of Gn used,while significant increases in endometrium thickness on the HCG day,E2 peak level,number of oocytes retrieved in group C2(P＜0.05).There were no significant differences in dosage and days of Gn used,endometrium thickness on the HCG day,E2 peak level,number of oocytes retrieved between group B2 and A2 (P ＞ 0.05).(3)There were no significant differences in number of high-quality embryos and clinical pregnancy rates among the different pretreatment groups between the two age groups(P＞0.05).Conclusions:No matter for women aged between 35 to 40 years old or over 40 years old,application of Co-enzyme Q10 combined with vitamin E plays a beneficial effect on ovary reserve and ovary response in women with advanced age.The results reveal an improvement tendency in IVF outcome but no statistical difference.关键词
高龄女性/卵巢功能低下/辅酶Q10/线粒体Key words
Advanced aged women/Decreased ovarian reserve/Co-enzyme Q10/Mitochondria引用本文复制引用
邹宇洁,尹太郎,李洁,王雅琴,徐望明,杨菁..辅酶Q10联合维生素E对高龄女性卵巢功能及IVF结局的影响[J].生殖医学杂志,2017,26(10):1028-1034,7.基金项目
湖北省卫计委面上项目(WJ2017MO11) （WJ2017MO11）
湖北省自然科学基金(2016CFB352) （2016CFB352）
中国国家留学基金(201706275124) （201706275124）
