生殖医学杂志2017，Vol.26Issue(10)：1047-1051,5.DOI:10.3969/j.issn.1004-3845.2017.10.018
卵母细胞代谢及其调节
Research progress of oocyte metabolism and its regulation
摘要
Abstract
The development and maturation of oocyte are dependent on ATP which comes from the highly active energy metabolism.It is the main energy procedure that oocytes produce ATP by the mitochondria oxidative phosphorylation with the glucose and/or its intermediate product,acetylformic acid,as substrate.Meanwhile,fatty and amino acids are also metabolic substrates in oocyte.Interestingly,there are species differences in the glycometabolism model.Besides energy,those metabolites and intermediate products play some roles in signal transduction,osmoregulation and so on.The oocyte metabolism is precisely controlled by the intracellular,intercellular and extracellular pathways.It is important to study oocyte metabolism and maturation mechanism in order to improve oocyte quality and efficiency of in vitro maturation(IVM).关键词
卵母细胞/卵丘细胞/线粒体/能量代谢/卵母细胞成熟Key words
Oocyte/Cumulus cells/Mitochondria/Energy metabolism/Oocyte maturation引用本文复制引用
徐文丹,崔毓桂,茅彩萍..卵母细胞代谢及其调节[J].生殖医学杂志,2017,26(10):1047-1051,5.基金项目
2017江苏省科教强卫工程项目(生殖医学创新平台,医学重点人才项目) （生殖医学创新平台,医学重点人才项目）
江苏省社会发展项目(BE20150642) （BE20150642）
国家自然基金(81370719,81671535) （81370719,81671535）
高校优势学科Ⅱ期建设过程(JX10231802) （JX10231802）
卫生厅妇幼保健重点专科(FXK201221) （FXK201221）
