眼科新进展2017，Vol.37Issue(10)：901-905,5.DOI:10.13389/j.cnki.rao.2017.0229
CRISPR/Cas9系统在视网膜发育与遗传性视网膜疾病研究中的应用
Application of CRISPR/Cas 9 system for the research of retinal development and inherited retinal diseases
摘要
Abstract
The system of clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated nuclease (Cas) 9 is an effective tool for revising the genome with great accuracy,and boost the advances in life science.By employing this system,we discover the regulation role of key gene during retina development and correct the abnormal mutation of these genes.In this paper,we summarize CRISPR-based technologies that enable mammalian genome editing and their various applications.And CRISPR/Cas9 may be a promising tool to disclosure the mechanism of retinal diseases so as to develop novel treatment for patients with retinitis pigmentosa.关键词
CRISPR/Cas9技术/基因编辑/遗传性视网膜疾病/发育/基因治疗Key words
CRISPR/Cas9/gene editing/genetic retinal disease/development/gene therapy分类
医药卫生引用本文复制引用
彭广华,王少军,杜璐..CRISPR/Cas9系统在视网膜发育与遗传性视网膜疾病研究中的应用[J].眼科新进展,2017,37(10):901-905,5.基金项目
国家重点基础发展计划基金资助(编号:2013CB967001) （编号:2013CB967001）
国家自然科学基金资助(编号:81501090)National Key Basic Research Program of China (No:2013CB967001) （编号:81501090）
National Natural Science Foundation of China (No:81501090) （No:81501090）
