眼科新进展2017，Vol.37Issue(10)：947-950,954,5.DOI:10.13389/j.cnki.rao.2017.0240
抗VEGF药物玻璃体内注射治疗视网膜血管样条纹继发脉络膜新生血管的远期观察
Long-term outcomes of intravitreal injection of anti VEGF medication in the treatment of choroidal neovascularization secondary to angioid streaks
摘要
Abstract
Objective To evaluate the long-term follow-up efficacy of intravitreal injection of anti-VEGF medication for choroidal neovascularization (CNV) caused by angioid streak.Methods A retrospective observational study was conducted in 21 patients (30 eyes) diagnosed as subfoveal CNV caused by angioid streak.Demographic data,clinical course,visual acuity,and findings of fluorescein angiography and optical coherence tomography (OCT) were evaluated and observed at least 3 years after antiVEGF treatment.Results Of all patients,the number of anti-VEGF injections was 6 to 18,with the average of 10 ±2.4,and the follow-up duration was 36 to 54 months,an average of (39.5 ± 2.2) months.Moreover,the mean best corrected visual acuity (BCVA) at the baseline was (31.0 ±3.81) characters,and the mean BCVA was (34.0 s0.35) characters at the final follow-up,and the total difference was not statistically significant (P =0.600).The baseline central retinal thickness (CRT) was (406.21 ± 21.23) im and (251.16 +36.36) μn at the end of the follow-up,and the difference of CRT before and after the treatment was statistically significant (P =0.002).Visual acuity of 16 eyes in 30 eyes was significantly improved after the initial treatment,but decreased to the baseline level in the follow-up because of CNV recurrence,10 eyes occurred varying degrees of macular atrophy and scarring changes,and there was no significant difference between visual acuity of the follow-up and the baseline (all P ＞0.05),and 4 eyes had stable CNV during the follow-up because the initial CNV did not involve the macular area.Conclusion The long-term outcomes of anti-VEGF treatment for choroidal neovascularization secondary to angioid streaks is not satisfactory due to its high recurrence and activity.关键词
抗VEGF/视网膜血管样条纹/脉络膜新生血管/OCTKey words
anti-VEGF medication/retinal angioid streaks/choroidal neovascularization/optical coherence tomography分类
医药卫生引用本文复制引用
黎铧,李娟娟..抗VEGF药物玻璃体内注射治疗视网膜血管样条纹继发脉络膜新生血管的远期观察[J].眼科新进展,2017,37(10):947-950,954,5.基金项目
云南省教育厅科学研究基金(编号:2015FB076) （编号:2015FB076）
云南省科技厅-昆明医科大学应用基础研究联合资金(编号:2015C043Y) （编号:2015C043Y）
云南省卫生和计划生育委员会医学后备人才培养计划(编号:H-201636)Scientific Research Fund of Educational Department of Yunnan Province (No:2015FB076) （编号:H-201636）
Joint Application of Basic Research Fund of Science and Technology Department of Yunnan Province-Kunming Medical University (No:2015C043Y) （No:2015C043Y）
Medical Reserve Talents of Yunnan Province (No:H-201636) （No:H-201636）
