中国医疗设备2017，Vol.32Issue(10)：110-117,8.DOI:10.3969/j.issn.1674-1633.2017.10.030
不可逆电穿孔治疗恶性肿瘤的数值模拟
Numerical Simulation Irreversible Electroporation Based Tumor Treatment
摘要
Abstract
The application of appropriate pulsed electric field to cells causes irreversible structure changes in cell membrane and eventually leads cell death. This phenomenon, known as irreversible electroporation (IRE) is emerging as a powerful tool for non-thermal tumor ablation therapy. Determination of the appropriate parameters to induce maximal damage to the tumor while sparing surrounding healthy tissue is vital for the success of irreversible electroporation-based cancer treatment. The purpose of this study herein is to summarize the general numerical simulation strategy of the irreversible electroporation cancer therapy. We first reviewed the numerical simulation studies on the irreversible electroporation cancer therapy in the past decade, then summarized the mechanisms of cell death during IRE and the design proposal of irreversible electroporation cancer therapy and finally illustrated the numerical simulation method of irreversible electroporation cancer therapy by Comsol Multiphysics examples.关键词
不可逆电穿孔/脉冲电场/肿瘤治疗/数值模拟/有限元分析Key words
irreversible electroporation/pulsed electric fields/oncotherapy/numerical simulation/finite element analysis分类
医药卫生引用本文复制引用
陈雪,吕毅,任冯刚,吴荣谦..不可逆电穿孔治疗恶性肿瘤的数值模拟[J].中国医疗设备,2017,32(10):110-117,8.基金项目
教育部创新团队发展计划(No.IRT16R57) （No.IRT16R57）
国家自然科学基金国家重大科研仪器研制项目(81727802). （81727802）
