应用化学2017，Vol.34Issue(10)：1127-1133,7.DOI:10.11944/j.issn.1000-0518.2017.10.170049
负载顺铂的泊洛沙姆温敏凝胶用于小鼠宫颈癌的局部化疗
Application of Cisplatin-loaded Thermosensitive Hydrogel in Local Chemotherapy of Cervical Cancer in Mice
摘要
Abstract
To explore the application of cisplatin-loaded thermosensitive hydrogel in the treatment of the cervical cancer in mice,cisplatin-loaded poloxamer thermosensitive hydrogel was prepared and characterized. The mouse uterine cervical cancer cell line U14 was injected into submucosa nearby the cervix in female mice. Drug-loaded hydrogel was infused into the vagina of tumor-bearing mice and the inhibitory effect was evaluated. The results show that the tumor inhibition rate is as high as 63. 1% by vaginal administration of cisplatin-loaded poloxamer hydrogel,which presents a new formulation for the local drug delivery via vagina against cervical cancer.关键词
顺铂/温敏凝胶/宫颈癌/泊洛沙姆Key words
cisplatin/thermosensitive hydrogel/cervical cancer/poloxamer分类
化学化工引用本文复制引用
王通,柳时,张秀英..负载顺铂的泊洛沙姆温敏凝胶用于小鼠宫颈癌的局部化疗[J].应用化学,2017,34(10):1127-1133,7.基金项目
国家自然科学基金(81602715)资助项目 Supported by the National Natural Science Foundation of China(No. 81602715) （81602715）
