中国病理生理杂志2017，Vol.33Issue(10)：1864-1868,5.DOI:10.3969/j.issn.1000-4718.2017.10.021
Mnk2蛋白水平与食管鳞癌预后的相关性
Correlation between Mnk2 protein expression and prognosis of patients with esophageal squamous cell carcinoma
摘要
Abstract
AIM:To investigate the protein expression of mitogen-activated protein kinase-interacting kinase-2 (Mnk2) and its prognostic effect in the patients with resected esophageal squamous cell carcinoma (ESCC).METHODS:A total of 86 informative patients with surgically resected ESCC and 54 normal esophageal tissues were enrolled .Western blot and immunohistochemistry (IHC) were utilized to assess the protein expression of Mnk 2, and its correlation with prog-nosis was statistically analyzed by the methods of Kaplan-Meier curve and Cox proportional hazard mode .RESULTS:The protein expression of Mnk 2 was elevated in most of tumor tissues compared with the adjacent tissues .Clinicopathologic analysis showed that Mnk2 expression was significantly correlated with the TNM stage (P<0.05).Both disease-free sur-vival ( DFS) and overall survival ( OS) of Mnk2 over-expression patients were shorter than those in Mnk 2 negative expres-sion group.Multivariate analysis confirmed that Mnk2 expression, as an independent and significant factor for both DFS and OS, predicted a poor prognosis of the patients with resected ESCC (P<0.05).CONCLUSION: The expression of Mnk2 was significantly related to the TNM stages , and might be a novel predictor for prognosis in ESCC .关键词
食管鳞癌/丝裂原活化蛋白激酶相互作用激酶2/预后因子Key words
Esophageal squamous cell carcinoma/Mitogen-activated protein kinase-interacting kinase-2/Prognosis factor分类
医药卫生引用本文复制引用
曾博,傅珉倚,冯沿芬,韩向前,邹大威,罗红鹤,雷艺炎..Mnk2蛋白水平与食管鳞癌预后的相关性[J].中国病理生理杂志,2017,33(10):1864-1868,5.基金项目
广东省医学科研基金资助项目(No.A2014217 （）
No.A2014246 （）
No.A2016297) （）
