中国病理生理杂志2017，Vol.33Issue(10)：1917-1920,4.DOI:10.3969/j.issn.1000-4718.2017.10.031
线粒体ROS与心房颤动
Mitochondrial reactive oxygen species and atrial fibrillation
摘要
Abstract
Atrial fibrillation ( AF) is the most common arrhythmia in clinical practice .Mitochondrial oxidative stress is supposed to contribute to development , progression and self-perpetuation of AF .Reactive oxygen species ( ROS) is the major molecule mediating mitochondrial oxidative stress damage .ROS can alter the redox status of various molecular targets, which quite specifically leads to functional alterations of ion channel activity or activation of a variety of redox sensi -tive signal transduction pathways .Eventually , it leads to atrial electrical remodeling and promotes the development of AF . Therefore, mitochondrial oxidative stress pathways may be a new target for the therapy of atrial fibrillation .关键词
线粒体/活性氧簇/离子通道/心房颤动Key words
Mitochondrial/Reactive oxygen species/Ion channel/Atrial fibrillation分类
医药卫生引用本文复制引用
郑安财,李菊香..线粒体ROS与心房颤动[J].中国病理生理杂志,2017,33(10):1917-1920,4.基金项目
江西省自然科学基金重大项目(No.20152ACB20025) （No.20152ACB20025）
江西省赣鄱555人才计划项目 （）
