中国动脉硬化杂志2017，Vol.25Issue(9)：874-878,5.
香青兰总黄酮对载脂蛋白E基因缺陷小鼠动脉粥样硬化病变形成的影响
The effect of total flavones of dracocephalum moldavica on atherosclerosis lesions of apolipoprotein E gene deficient mice
摘要
Abstract
Aim To investigate the effect and possible mechanism of total flavones of dracocephalum moldavica (TFDM) on atherosclerosis lesions in apolipoprotein E gene deficient (ApoE-/-) mice.Methods ApoE-/-mice were randomly divided into model group,simvastatin group and TFDM high,medium,low dose group,C57BL/6J mice were set as the normal control group.After treated for 12 weeks,the mice were sacrificed and plasma lipids were determined,the area of atherosclerotic plaques and the ratio of plaque area to aorta were measured by HE staining,the expressions of intercellular cell adhesion molecule-1 (ICAM-1),vascular cell adhesion molecule-1 (VCAM-1),proliferating cell nuclear antigen (PCNA) in aortic atherosclerotic lesions were detected by immunohistochemistry analysis.Results Compared with the model group,the levels of triglyceride (TG) and low density lipoprotein cholesterol (LDLC) was decreased significantly in treatment group.The atherosclerotic lesions reduced and the ratio of plaque area to aorta decreased in TFDM groups.The expression of ICAM-1,VCAM-1 and PCNA were down-regulated by TFDM.Conclusion TFDM can inhibit atherosclerosis formation which involved in decreasing the level of plasma lipids and weakening the expression of ICAM-1,VCAM-1 and PCNA in the aorta wall.关键词
香青兰总黄酮/动脉粥样硬化/细胞间黏附分子1/血管细胞黏附分子1/增殖细胞核抗原Key words
Total flavones of dracocephalum moldavica/Atherosclerosis/Intercellular cell adhesion molecule-1/Vascular cell adhesion molecule-1/Proliferating cell nuclear antigen分类
医药卫生引用本文复制引用
全翊宁,王新春,郭新红,袁勇,曹文疆,程江..香青兰总黄酮对载脂蛋白E基因缺陷小鼠动脉粥样硬化病变形成的影响[J].中国动脉硬化杂志,2017,25(9):874-878,5.基金项目
国家自然科学基金项目(81460638 （）
81660704 （）
81360631) （）
