中国动脉硬化杂志2017，Vol.25Issue(9)：914-918,5.
佐匹克隆对Ⅰ级高血压合并睡眠障碍患者血压的影响
The effects of zopiclone on patients of type Ⅰ essential hypertension combined with dyssomnia
摘要
Abstract
Aim To investigate the effects of zopiclone on patients of type Ⅰ essential hypertension combined with dyssomnia and explore its mechanism of action.Methods Patients with essential hypertension combined with dyssomnia were included and randomly assigned in two groups:non-drug treatment of patients were provided with lifestyle management advices including control of salt intake,physical exercise,prohibiting use of cigarettes and alcohols and improving food diversity;patients in the zopiclone group were given zopiclone along with the same lifestyle advices.The Pittsburgh Sleep Quality Index (PQSI),blood pressures (BPs),plasma renin activity (PRA),blood concentration of angiotension Ⅱ (Ang Ⅱ) and aldosterone (ALD) before and after the treatment were compared.Results Zopiclone showed significant course-dependent effect of lowering PSQI and improving quality of sleep (P＜0.05,P＜0.01,respectively),the outcome of the zopiclone group was better than non-drug group (P＜0.001).After 6 weeks' therapy,SBP and DBP of the zopiclone group patients were lower than the non-drug group (P＜0.05,P＜0.01).Meanwhile,improvements in PRA,Ang Ⅱ and ALD were more significant as well compared to the non-drug group (P＜0.05,P＜0.01).Conclusion Zopiclone is effective in controlling the blood pressures of patients with type Ⅰ essential hypertension combined with dyssomnia,and deactivating RAAS by improving sleep-disorder is possibly involved in its effects.关键词
高血压/睡眠障碍/肾素-血管紧张素-醛固酮系统/佐匹克隆Key words
Hypertension/Dyssomnia/Renin aniotension aldosterone system/Zopiclone分类
医药卫生引用本文复制引用
刘科峰,彭忠禄,罗祎敏..佐匹克隆对Ⅰ级高血压合并睡眠障碍患者血压的影响[J].中国动脉硬化杂志,2017,25(9):914-918,5.基金项目
湖南省教育厅资助科研项目(12C0893、17C1384) （12C0893、17C1384）
湖南省重点建设学科资金资助(湘教发[2011]76号) （湘教发[2011]76号）
湖南省高校重点实验室资金资助(湘教通[2008] 246号) （湘教通[2008] 246号）
