中国动脉硬化杂志2017，Vol.25Issue(9)：919-922,4.
慢性肾脏病患者成纤维细胞生长因子23、Klotho蛋白与颈动脉内膜中膜厚度的相关性
Relationship between fibroblast growth factor 23, Klotho protein and carotid intima-media thickness in patients with chronic kidney disease
摘要
Abstract
Ain To investigate the relationship between serum levels of fibroblast growth factor 23 (FGF-23),Klotho protein and carotid atherosclerosis in non-dialysis patients with chronic kidney disease (CKD) 2-5 stage.Methods 126 CKD 2-5 stage patients were involved in the study.Carotid intima-media thickness (CIMT) was measured by color Doppler ultrasonography.The patients were divided into CIMT thickening group and CIMT normal group according to CIMT.Serum levels of FGF-23 and Klotho protein were determined by enzyme-linked immunosorbem assay,and the general data and clinical biochemical indexes were collected.The relative indexes of the two groups were compared,and the correlation between FGF-23,Klotho protein and carotid atherosclerosis was analyzed.Unconditional Logistic regression analysis was used for multivariate analysis of CIMT influencing factors.Results The serum FGF-23 level in CIMT thickening group was significantly higher than that in CIMT normal group (435.39±221.20 vs 360.22±194.26,P＜0.05),and the level of Klotho protein was significantly lower than that in CIMT normal group (446.54± 132.49 vs 499.36± 121.38,P＜0.05).Multivariate stepwise regression analysis showed that Klotho protein was an independent protective factor for CIMT thickening in patients with CKD (OR=1.086,P＜0.05),while age increase and FGF-23 were independent risk factors for CIMT thickening in patients with CKD (OR =1.075,P＜0.05;OR =1.238,P＜0.05).Conclusion CIMT thickening is related to FGF-23 and Klotho proteins in non-dialysis patients with CKD 2-5 stage.FGF-23 and Klotho protein play an important role in the occurrence and development of carotid atherosclerosis.关键词
慢性肾脏病/成纤维细胞生长因子23/Klotho蛋白/颈动脉内膜中膜厚度Key words
Chronic kidney disease/Fibroblast growth factor 23/Klotho protein/Carotid intima-media thickness分类
医药卫生引用本文复制引用
陈金艳,胡勇,孙红,姜婷,刘先英..慢性肾脏病患者成纤维细胞生长因子23、Klotho蛋白与颈动脉内膜中膜厚度的相关性[J].中国动脉硬化杂志,2017,25(9):919-922,4.基金项目
青岛市中医药科研计划(2017-zyx015) （2017-zyx015）
