中国动脉硬化杂志2017，Vol.25Issue(9)：923-927,5.
血清非高密度脂蛋白胆固醇对缺血性脑卒中患者急性期神经功能损害的影响
The influence of serum non-high-density lipoprotein cholesterol on neurologic impairment in patients with acute ischemic stroke
摘要
Abstract
Aim The purpose of this study was to explore the influence of serum non-high-density lipoprotein cholesterol (non-HDLC) on neurologic impairment in patients with acute ischemic stroke and its clinical value in disease risk assessment.Methods A total of 611 cases of acute ischemic stroke patients were recruited in this study.NIHSS (National Institute of Health stroke scale),CSS(China Stroke scale),ESS(Europe Stroke Scale) and BI(Barthel Index)were used to evaluate the degree of neurologic impairments.Fasting plasma glucose (FPG),hypersensitive c-reactive protein(hs-CRP),glycosylated hemoglobin (HbA1c),homocysteine (Hcy),total cholesterol (TC),triglyceride (TG),high-density lipoprotein cholesterol (HDLC) and low density lipoprotein cholesterol (LDLC) were measured in all the patients.Then the density of non-HDLC were calculated with the formula of TC minus HDLC.Results Patients with high level of serum non-HDLC had bigger body mass index,higher NIHSS,CSS and BI scores,lower ESS and elevated TC,TG,LDLC,Hcy,FPG,HbAlc,lower HDLC levels.The NIHSS scores changed corresponding with serum nonHDLC level in acute ischemic stroke patients,the total scores of NIHSS,CSS were positively correlated with the serum nonHDLC level,and the total scores of ESS,and BI were negatively correlated with it.High serum level of non-HDLC was an independent risk factor for neurologic impairment in patients with acute ischemic stroke,when serum non-HDLC elevated to borderline high level,the risk of neurologic impairment significantly increased.Conclusion Increased serum nonHDLC level was an independent risk factor of neurologic impairmem in patients with acute cerebral ischemia,it would be an effective indicator,and target of the prevention and treatment as well,of risk prediction for neurologic impairment in patients with acute cerebral ischemia.关键词
血脂异常/非高密度脂蛋白胆固醇/急性缺血性卒中/神经功能损害Key words
Dyslipidemia/Non-high density lipoprotein cholesterol/Ischemic stroke/Neurologic impairment分类
医药卫生引用本文复制引用
陆达,郑娜,李攀,田志岩,张惠红,周玉颖,徐小林..血清非高密度脂蛋白胆固醇对缺血性脑卒中患者急性期神经功能损害的影响[J].中国动脉硬化杂志,2017,25(9):923-927,5.基金项目
天津市科技计划项目(13ZCZDSY0 1600) （13ZCZDSY0 1600）
天津市卫生局科技重点项目(13K G121) （13K G121）
