摘要
Abstract
Aim To explore the relationship between lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and carotid atherosclerotic plaque in patients with acute cerebral infarction (ACI).Methods A total of 82 ACI patients from June 2013 to October 2014 in our hospital were selected as cerebral infarction group,and a total of 82 healthy people were selected as control group.The total carotid atherosclerotic plaque score were tested by color Doppler ultrasound.The serum Lp-PLA2 levels were detected by ELISA.The relationship between serum Lp-PLA2 levels and acute cerebral infarction size,carotid atherosclerotic plaque Crouse score in patients were analyzed by Spearman correlation.Results The Lp-PLA2,hs-CRP,TG,TC and LDLC levels in infarction patients were significantly higher than those in control group,HDLC levels were significantly lower than that in control group (P＜0.05).Crouse score,Lp-PLA2 levels had significant differences among the three groups of carotid atherosclerotic plaque block grade Ⅰ,Ⅱ,Ⅲ.Lp-PLA2 levels increased with the grade and the degree of injury (P＜ 0.05).Lp-PLA2 levels was positively correlated to Crouse score,infarct size (r=0.823 and r=0.879,all P＜0.05).Conclusion It shows that Lp-PLA2 levels and atherosclerotic cerebral infarction are closely related,Lp-PLA2 levels may reflect carotid atherosclerotic plaque and infarct size,which can be used as predictors of cerebral infarction.关键词
急性脑梗死/脂蛋白相关磷脂酶A2/高密度脂蛋白/颈动脉粥样硬化Key words
Acute cerebral infarction/Lipoprotein-associated phospholipase A2/High density lipoprotein/Carotid atherosclerosis分类
医药卫生
