中国动脉硬化杂志2017，Vol.25Issue(9)：941-947,7.
阿司匹林与氯吡格雷预防或治疗缺血性脑卒中致出血并发症的系统评价
Bleeding complications caused by preventing or treating of aspirin and clopidogrel for ischemic stroke: a systematic review
摘要
Abstract
Aim To assess the bleeding complications caused by preventing or treating of aspirin and clopidogrel for ischemic stroke (IS).Methods The databases including PubMed,EMBase,The Cochrane Library,CBM,CNKI,VIP and Wang Fang Data were retrieved by using computer,and retrieval was from the database building until September 2016.The randomized controlled trials (RCT) were collected on aspirin and clopidogrel to prevent or treat IS and causing bleeding complications.The Meta analysis was carried out by RevMan 5.2 software after 2 researchers independently conducted literature screening,data extraction and quality evaluation.Results A total of 13 RCTs,including 5204 patients,were enrolled.Meta analysis showed:(1) In the prevention of IS,compared with clopidogrel,aspirin did not increase the risks of mucoeutaneous and gingival bleeding,but increased the risk of gastrointestinal bleeding;Compared with aspirin alone,aspirin and clopidogrel combination increased gastrointestinal response.(2)In the treatment of IS,compared with clopidogrel,aspirin did not increase the risks of mucocutaneous,gingival bleeding and gastrointestinal bleeding,without increasing gastrointestinal response;Compared with aspirin alone,the combination of aspirin and clopidogrel did not increase the risks of skin,mucous membranes,gums,digestive tract and brain hemorrhage,and did not increase the gastrointestinal response.Conclusion In the prevention of IS,aspirin can increase the risk of gastrointestinal bleeding when compared with clopidngrel,and the combination of aspirin and clopidogrel can increase gastrointestinal response when compared with aspirin alone.关键词
缺血性脑卒中/出血并发症/阿司匹林/氯吡格雷/Meta分析Key words
Ischemic stroke/Bleeding complication/Aspirin/Clopidogrel/Meta analysis分类
医药卫生引用本文复制引用
许风雷,殷振江,王国团,张卫东,刘关键..阿司匹林与氯吡格雷预防或治疗缺血性脑卒中致出血并发症的系统评价[J].中国动脉硬化杂志,2017,25(9):941-947,7.基金项目
克拉玛依市科委立项项目(JK2014-18) （JK2014-18）
