中国动脉硬化杂志2017，Vol.25Issue(9)：957-962,6.
慢性内质网应激诱导的凋亡在动脉粥样硬化斑块形成中的作用
Role of chronic endoplasmic reticulum stress induced apoptosis in atherosclerotic plaque formation
摘要
Abstract
The endoplasmic reticulum stress (ERS) has emerged as a factor that is relevant to a number of systemic and arterial-wall factors that promote atherosclerosis (As).Prolonged activation of ERS pathway known as the unfolded protein response (UPR) can lead to cell pathology and subsequent tissue dysfunction.There is now ample evidence that the UPR is chronically activated in atherosclerotic lesional cells,particularly advanced lesional macrophages and endothelial cells.The stressors in advanced lesions that can lead to prolonged activation of the UPR include oxidative stress,oxysterols,and high levels of intracellular cholesterol and saturated fatty acids.These arterial-wall stressors may be especially prominent in the settings of obesity,insulin resistance,and diabetes,all of which promote the clinical progression of As.While exciting work over the last decade has begun to shed light on the mechanisms and in vivo relevance of ERS-driven As,much more work is needed to fully understand this area and to enable an informed approach to therapeutic translation.关键词
内质网应激/动脉粥样硬化/未折叠蛋白反应/内皮细胞/巨噬细胞Key words
Endoplasmic reticulum stress/Atherosclerosis/Unfolded protein response/Endothelial cells/Macrophage分类
医药卫生引用本文复制引用
景怡,蔡丹凤,林超,孙鑫,卞慧敏..慢性内质网应激诱导的凋亡在动脉粥样硬化斑块形成中的作用[J].中国动脉硬化杂志,2017,25(9):957-962,6.基金项目
国家自然科学基金项目(81173190) （81173190）
江苏省中医药管理局项目(LZ11191) （LZ11191）
江苏省高校优势学科建设工程资助项目(ysxk-2010) （ysxk-2010）
南京中医药大学中药学一级学科开放课题资助(2011zyx4-004) （2011zyx4-004）
国家科技重大专向:重大新药创制(2011ZX09102-002-07) （2011ZX09102-002-07）
