中国防痨杂志2017，Vol.39Issue(10)：1130-1133,4.DOI:10.3969/j.issn.1000-6621.2017.10.019
二甲双胍研究进展及其在结核病治疗中的应用前景
Research progress of metformin and its application prospect in treatment of tuberculosis
摘要
Abstract
The prevalence and mortality of tuberculosis (TB) are still high,and new treatment methods and strategies are urgently needed.Metformin (MET),as a first-line drug for treatment of type two diabetes mellitus (D2M),also plays the positive roles in treatment of other diseases.In this paper,the research history and progress of the MET development were reviewed,and its potential role and mechanism in anti TB treatment were introduced.MET can activate the pathway of AMP-activated protein kinase (AMPK),promote the generation of reactive oxygen species(ROS) and inhibit the bacterial oxidation respiratory chain complex (NDH-I) to enhance the ability of the host against Mycobacterium tuberculosis.MET also has some anti-inflammatory effects,and it plays a positive role in the treatment of TB.MET can also induce the autophagy of the infected cells and enhance the efficacy of the conventional anti-TB drugs.关键词
二甲双胍/结核/治疗应用/综述Key words
Metformin/Tuberculosis/Therapeutic use/Review引用本文复制引用
刘浩然,李传友,王伟,高孟秋..二甲双胍研究进展及其在结核病治疗中的应用前景[J].中国防痨杂志,2017,39(10):1130-1133,4.基金项目
北京市医院管理局“登峰”计划(DFL20151501) （DFL20151501）
北京市通州区科技计划(KJ2017CX076) （KJ2017CX076）
