中国免疫学杂志2017，Vol.33Issue(10)：1478-1482,5.DOI:10.3969/j.issn.1000-484X.2017.10.008
MIC基因多态性与解脲脲原体感染的易感关联性研究
Study on association between MIC gene polymorphism and ureaplasma urealyt-icum infection
李瑜 1陈恩 2陈纯静 3曾凡胜 1周琳 1曾威4
作者信息
- 1. 益阳医学高等专科学校,益阳 413000
- 2. 南华大学附属第一医院,衡阳 421001
- 3. 长沙医学院,长沙 410219
- 4. 益阳市中心医院,益阳 413000
- 折叠
摘要
Abstract
Objective:To investigate the association between MIC allele polymorphism and susceptibility to Ureaplasma urealyticum infection. Methods:PCR-SSP and PCR-SBT were used to analyze the gene polymorphism of every one. Results:Twelve allele genes of MICA and five MICA-STR and fourteen MICB were found in the participants,the frequency of MICA?010 and MICB?009N were higher in ureaplasma urealyticum infection patients than in healthy controls(MICA?010:OR=3. 85,95%CI:2. 12-6. 99, Pc<0. 05;MICB?009N:OR=3. 22,95%CI:1. 33-7. 80,Pc<0. 05);the frequencies of MICA-A5. 1 and MICB?00502 were lower in ureaplasma urealyticum infection patients than in healthy controls(MICA-A5. 1:OR=0. 61,95%CI:0. 40-0. 94,Pc<0. 05;MICB?00502:OR=0. 58,95%CI:0. 40-0. 83,Pc<0. 05),the differences were statistically significant;MICA?010/010,MICA?01201/01201 homozygote were higher in ureaplasma urealyticum infection patients than in healthy controls(MICA?010/010:OR=14. 84, 95%CI:1. 90-115. 9,Pc<0. 05:MICA?01201/01201:OR=10. 83,95%CI:1. 35-86. 79,Pc<0. 05),the differences were statistically significant. The distribution frequency of MICB?00502/00502 in patients with ureaplasma urealyticum was higher,but the difference was not statistically significant(Pc>0. 05). Conclusion:MIC allele gene polymorphism may be associated with ureaplasma urealyticum infection.关键词
MIC基因/基因多态性/解脲脲原体Key words
MIC alleles/Gene polymorphism/Ureaplasma urealyticum分类
医药卫生引用本文复制引用
李瑜,陈恩,陈纯静,曾凡胜,周琳,曾威..MIC基因多态性与解脲脲原体感染的易感关联性研究[J].中国免疫学杂志,2017,33(10):1478-1482,5.
