中国免疫学杂志2017，Vol.33Issue(10)：1536-1538,1542,4.DOI:10.3969/j.issn.1000-484X.2017.10.019
七氟烷麻醉抑制急性创伤性颅脑损伤患者围手术期炎症介质的表达
Sevoflurane influenced inflammatory response on surgery patients with traumatic brain injury
摘要
Abstract
Objective:To investigate the effects of Sevoflurane on inflammatory response,neuro damage and the prognosis on surgery patients with traumatic brain injury ( TBI ) . Methods:From July 2015 to December 2016, 80 TBI patients undergoing neurosurgery were randomly divided into experimental group ( Sevoflurane treatment, n=40 ) and control group ( n=40 ) . The serum levels of TNF-α,IL-6,C-reactive protein ( CRP) and neuron specific enolase ( NSE) were tested with enzyme linked immunosorbent Assay (ELISA). GCS score,APACHEⅡ score and prognosises of the two groups were also compared. Results:Compared with control group,the serum levels of inflammatory related factors (CRP,TNF-α,IL-6) in the experimental group were significantly decreased in 1 hour of intraoperative,at the end of surgery and on 1st day after surgery respectively ( P<0. 05 or 0. 01 ) . Meanwhile, NSE protein expressions were significantly decreased(P<0. 05 or 0. 01). The experimental group received better prognosis compared to the control group,GCS scores[(10. 82±1. 40) vs (8. 29±1. 02),P=0. 03],APACHEⅡ scores[(14. 42±1. 97) vs (18. 03±2. 15),P=0. 02]on the 14th day. Conclusion:Sevoflurane treatment can effectively regulate the inflammatory response, reduce the neurons damage in surgery patients with TBI,possibly playing brain protection effect.关键词
创伤性颅脑损伤/七氟烷/炎症反应/神经保护Key words
Traumatic brain injury/Sevoflurane/Inflammatory response/Neuroprotection分类
医药卫生引用本文复制引用
官瑞婷,高宏志,梁双吟..七氟烷麻醉抑制急性创伤性颅脑损伤患者围手术期炎症介质的表达[J].中国免疫学杂志,2017,33(10):1536-1538,1542,4.基金项目
本文为福建省自然科学基金项目(No.J[2015]01383). （No.J[2015]01383）
