中国实用儿科杂志2017，Vol.32Issue(9)：687-692,6.DOI:10.19538/j.ek2017090610
青少年急性淋巴细胞白血病临床特征及预后分析
Clinical characteristics and outcome of adolescent patients with acute lymphoblastic leukemia
摘要
Abstract
Objective To summarize the clinical characteristics and outcome of adolescent patients with acute lymphoblastic leukemia (ALL) treated with Chinese Children's Leukemia Group (CCLG)-2008 protocol over a 5-year period from 2008 to 2013.Methods Clinical features,immunophenotypes,cytogenetic abnormalities and prognosis of adolescent patients aged 10 to 18 were compared with younger patients under 10 years old.Results During 2008-2012,723 patients with ALL were enrolled in our study.About 14.11％ of them were 10-to 18-year old patients.Compared to younger ones,adolescent patients demonstrated a higher incidence of T-cell lineage phenotype (14.71％ vs 5.8％),t (9;22) (8.82％ vs.4.99％),t (1;19) (8.82％ vs.5.15％),and significantly lower frequency of t (12;21)(21.74％ vs.8.82％).In intermediate group,the 5-year overall survival rate(OS) and event-free survival rate(EFS) of adolescent patients was compatible with paediatric patients,(92.88％ vs.90.86％) and (77.09％ vs.82.9％),respectively.However,the EFS of adolescent patients with high-risk ALL was worse than paediatric patients (42.78％ vs.54.12％).Conclusion Despite the increased incidence of adverse prognostic factors,the survival rate of adolescent patients has been improved when treated with paediatric ALL protocol.However,the poor prognosis of adolescent patients in the high-risk group remains to be the current challenge.关键词
青少年/急性淋巴细胞白血病/临床特征/预后Key words
adolescents/acute lymphoblastic leukemia/clinical characteristics/outcome分类
医药卫生引用本文复制引用
于皎乐,吴敏媛,张瑞东,谢静,张元元,吴颖,高超,林巍,郑胡镛..青少年急性淋巴细胞白血病临床特征及预后分析[J].中国实用儿科杂志,2017,32(9):687-692,6.基金项目
北京市医院管理局青苗人才计划(QML20161202) （QML20161202）
国家自然科学基金青年基金(81400074) （81400074）
北京市医院管理局登峰人才培养计划团队(DFL20151101) （DFL20151101）
北京市医院管理局临床医学发展专项经费资助(ZY201404) （ZY201404）
首都卫生发展科研专项-重点攻关(首发2016-1-2091) （首发2016-1-2091）
