中国实用内科杂志2017，Vol.37Issue(9)：794-797,4.DOI:10.19538/jnk2017090105
移植肾C3肾小球病的诊治
Diagnosis and treatment of C3 glomerulopathy of transplant kidney
文吉秋1
作者信息
- 1. 南京总医院国家肾脏疾病临床医学研究中心,江苏南京210000
- 折叠
摘要
Abstract
C3 glomerulopathy is a newly proposed disease entity which is characterized by predominantly complement C3 deposition in the glomeruli.C3 glomerulopathy has 2 variants,including C3 glomerulonephritis and dense deposit disease.This disease carries a high risk of post-kidney transplant recurrence.The underlying pathophysiology is the acquired or inherited complement factor abnormalities or dysregulation of complement regtlating system,leading ultimately to persistent C3 activation and its deposition in the mesangium and glomerular basement membrane.Therefore,genetic testing plays an important role in management and is conducive to understanding the pathogenesis of C3 glomerulopathy.The clinical manifestations of C3 glomerulopathy are non-specific,including hematuria,proteinuria and serum creatinine elevation.Renal allograft biopsy frequently shows membranoproliferative glomerulanephritis-like pattern.Currently,there is no specific treatment for recurrent C3 glomerulopathy.Monoclonal antibody eculizumab has only been shown to be effective in a subset of patients.Therefore,the effect and side-effects of eculizumab should be verified in the future in large number of cases.关键词
C3肾小球病/肾移植/Eculizumab/基因检测Key words
C3 glomerulopathy/kidney transplant/Eculizumab/genetic testing分类
医药卫生引用本文复制引用
文吉秋..移植肾C3肾小球病的诊治[J].中国实用内科杂志,2017,37(9):794-797,4.
