中国现代医学杂志2017，Vol.27Issue(21)：7-11,5.DOI:10.3969/j.issn.1005-8982.2017.21.002
布地奈德联合辛伐他汀对慢性阻塞性肺疾病大鼠炎症因子与肺组织病理的影响
Synergistic effect of Budesonide and Simvastatin on cytokines and lung histological injury in rat models of COPD
摘要
Abstract
Objective To investigate synergistic effect of Budesonide and Simvastatin on cytokines and pulmonary histological injury in rat models of chronic obstructive pulmonary disease (COPD) so as to provide indications for novel pharmacological intervention.Methods Rats were randomly divided into model (M) group,Budesonide (BD) group,Simvastatin (SV) group and Budesonide combined with Simvastatin (BD+SV) group.Levels of interleukin 6 (IL-6),interleukin 8 (IL-8),leukotriene B4 (LTB4) and tumor necrosis factor alpha (TNF-α) in serum and bronchoalveolar lavage fluid (BALF) were measured.Histological injury was graded in rat lung slices.Results Inflammatory cytokines in serum:compared with the M group,levels of IL-6 and TNF-α in the BD group,IL-6 in the SV group,and IL-6,IL-8 and TNF-α in the BD+SV group were decreased (P＜ 0.05).The level of IL-8 was attenuated in the BD+SV group compared with those in the SV group (P ＜ 0.05).Inflammatory cytokines in BALF:the levels of IL-6 and IL-8 in the BD group,IL-6 and TNF-α in the SV group,and IL-6,IL-8,LTB4 and TNF-α in the BD+SV group were reduced compared with those in the M group (P ＜ 0.05).Levels of IL-8,LTB4 and TNF-α in the BD+SV group were decreased in comparison with those in the BD group.Levels of IL-8 and LTB4 could be diminished by BD+SV treatment when compared with the SV group (P ＜ 0.05).Semi-quantitative scores of pathological changes of lung tissues in the BD group,the SV group and the BD+SV group were lower than those in the M group (P＜ 0.05),the lung tissues showed reduced cyst cavities and alleviated bronchitis.Conclusions Budesonide combined with Simvastatin could synergistically relieve systematic and airway inflammation,and attenuate histological injury in the lungs of COPD rat models.关键词
肺疾病/慢性阻塞性/炎症/布地奈德/辛伐他汀Key words
chronic obstructive pulmonary disease/inflammation/Budesonide/Simvastatin分类
医药卫生引用本文复制引用
刘晓姝,郭璐..布地奈德联合辛伐他汀对慢性阻塞性肺疾病大鼠炎症因子与肺组织病理的影响[J].中国现代医学杂志,2017,27(21):7-11,5.基金项目
四川省科技厅基础研究计划项目(No:2013JY0177) （No:2013JY0177）
