中国现代医学杂志2017，Vol.27Issue(21)：54-60,7.DOI:10.3969/j.issn.1005-8982.2017.21.010
循环微粒对口腔癌进展的作用机制研究
Role of CMPs in development of oral squamous cell carcinoma
祝华珺 1汤晶 1葛自力1
作者信息
- 1. 苏州大学附属第一医院口腔科,江苏苏州215006
- 折叠
摘要
Abstract
Objective To evaluate the role of circulating microparticles (CMPs) in the development of oral squamous cell carcinoma (OSCC).Methods CMPs were isolated by gradient centrifuge from healthy volunteers and OSCC patients.Cell proliferation was determined by MTT assay and EdU test.Migration and invasion activity were evaluated by wound healing assay and Transwell,respectively.Nude mouse models were utilized to evaluate tumorigenesis capacity of OSCC xenograft with or without CMPs.Results The concentration of CMPs was significantly higher in OSCC patients compared with healthy volunteers,and the increase of CMPs was closely associated with hyper-coagulation status.The ability of proliferation,migration,invasion and tumorigenesis of CAL27 cells were significantly enhanced by OSCC-derived CMPs.Conclusions OSCC-derived CMPs can increase proliferation,migration,invasion and tumorigenesis of CAL27 cells.关键词
循环微囊泡/口腔癌/增殖/迁移/侵袭Key words
circulating mircroparticles/oral squamous cell carcinoma/proliferation/migration/invasion分类
医药卫生引用本文复制引用
祝华珺,汤晶,葛自力..循环微粒对口腔癌进展的作用机制研究[J].中国现代医学杂志,2017,27(21):54-60,7.
