王川林 1刘娇 1古雪 1梅怡晗 2李铃 1朱其荣1
作者信息
- 1. 川北医学院附属医院感染科,四川南充637000
- 2. 首都医科大学,北京100069
- 折叠
摘要
Abstract
Objective To explore the correlations between expression levels of serum inflammatory cytokines and pathogens,degree of disease and prognosis in blood infectious diseases.Methods A total of 97 cases of bloodstream infections were included in this retrospective analysis from January 2015 to May 2016.The expression levels of procalcitonin (PCT),C-reactive protein (CRP),interleukin 6 (IL-6),white blood cell count (WBC) and tumor necrosis factor alpha (TNF-α) were analyzed according to patients' condition,types of pathogenic bacteria,and treatment effect.Results The levels of serum inflammatory cytokines of patients with positive blood culture were significantly higher than those with negative blood culture,the differences were statistically significant [PCT (t=170.410,P=0.000);IL-6 (t=187.223,P=0.000);WBC (t=19.244,P=0.000);CRP (t=47.941,P=0.000);TNF-α (t=20.484,P=0.000)].The levels of serum inflammatory factors PCT,IL-6,WBC,CRP and TNF-o were the highest in Gram-negative bacteria group,and the lowest in fungus group,of which the differences were statistically significant [PCT(F=5.367,P=0.019);IL-6 (F=10.321,P=0.001);WBC (F =9.587,P=0.000);CRP (F =15.894,P=0.000);TNF-ct (F=13.254,P =0.000)].There was significant difference between each compared group (P＜ 0.05).Expression levels of serum inflammatory cytokines of blood flow infected patients in the ineffective group were significantly increased.Tbere was significant difference between preand post-treatment group (P ＜ 0.05).Serum inflammatory cytokine expression levels of bloodstream infected patients in the effective group were significantly decreased,there was significant difference between the two groups (P ＜ 0.05).Expression levels of serum inflammatory cytokines of blood flow infected patients were significantly different between the effective and the ineffective groups (P ＜ 0.05).Conclusions There are some correlations between the expression levels of serum inflammatory cytokines and the severity of blood infectious diseases or pathogenic bacteria species,which is of some value to early judgment of therapeutic effect.关键词
炎症因子/血流感染/病原菌Key words
inflammatory factor, bloodstream infections/pathogenic bacteria分类
医药卫生
