中国药房2017，Vol.28Issue(27)：3774-3777,4.DOI:10.6039/j.issn.1001-0408.2017.27.08
阿卡波糖联合二甲双胍对2型糖尿病患者相关指标的影响
Effects of Acarbose Combined with Metformin on Related Indexes of Patients with Type 2 Diabetes
摘要
Abstract
OBJECTIVE:To investigate the effects of acarbose combined with metformin on related indexes of patients with type 2 diabetes mellitus.METHODS:A total of 100 patients with type 2 diabetes mellitus were randomly divided into control group (50 cases) and observation group (50 cases).Control group was given Acrbose tablet 50 mg orally,3 times a day.Observation group was additionally given Metformin hydrochloride tablet 0.5 g orally,3 times a day,on the basis of control group.Both groups were treated for 12 weeks.The levels of fasting plasma glucose (FPG),fasting plasma insulin (FINS),glycosylated hemoglobin (HbA1c),2 h postprandial plasma glucose (2 hPG),postprandial 2 h insulin (2 hFINS),insulin resistance index (HOMA-IR),the proportion of Th cell subsets in CD4+ T cells,IL-22,IL-17A and IFN-γ,mRNA expression of IL-22,IL-17A and IFN-γ were observed in 2 groups before and after treatment.The occurrence of ADR was recorded.RESULTS:After treatment,FPG,FINS,HbA1c,2 hPG,2 hFINS,HOMA-IR,the proportion of Th cell subsets in CD4+ T cells,the concentrations of IL-22,IL-17A and IFN-γ,expression of IL-22 mRNA,IL-17A mRNA and IFN-γ mRNA in 2 groups were significantly lower than before treatment,with statistical significance (P＜0.05);there was no significant difference in the proportion of Th1 in T cells between 2 groups (P＞0.05).Other indexes of observation group were significantly lower than those of control group,with statistical significance (P＜0.05).There was no statistical significance in the incidence of ADR between 2 groups (P＞0.05).CONCLUSIONS:For patients with type 2 diabetes mellitus,acarbose combined with metformin can effectively control the level of blood glucose,improve insulin resistance,balance Th cell subsets,reduce inflammatory factors levels but don't increase the occurrence of ADR.关键词
阿卡波糖/二甲双胍/2型糖尿病/CD4+T细胞亚群/炎性细胞因子/胰岛素抵抗/血糖Key words
Acarbose/Metformin/Type 2 diabetes mellitus/CD4+ T cell subset/Inflammatory factors/Insulin resistance/Blood glucose分类
医药卫生引用本文复制引用
庞宁,陈科,彭皓均,郑碧波..阿卡波糖联合二甲双胍对2型糖尿病患者相关指标的影响[J].中国药房,2017,28(27):3774-3777,4.基金项目
广东省中医药局科研课题(No.20142062) （No.20142062）
