中国药业2017，Vol.26Issue(19)：19-23,5.DOI:10.3969/j.issn.1006-4931.2017.19.005
大黄蒙医酒焖炮制机理及有效性研究
Processing Mechanism and Effectiveness of Rheum Palmatum with Wine-Steaming According to Mongolian Medicine
摘要
Abstract
Objective To investigate the processing mechanism of Rheum palmatum with wine-steaming according to Mongolian medicine, and to optimize the wine-steaming processing technology and make an initial about safety and efficiency of processed Rheum palmatum. Methods HPLC method was used to analyze the content of total anthraquinone and free anthraquinone in Rheum palmatum and wine-steaming processed Rheum palmatum, the Rheum palmatum was processed by wine-steaming, with the ratio of herbs and wine, stewing time and heating time as 3 factors, each factor was selected at 3 levels for orthogonal test, and the optimum technological conditions were optimized. The safety and efficacy of Rheum palmatum Decoction were evaluated through the laxative effect and acute toxicity test of wine-steaming processed Rheum palmatum on mice. Results The content of anthraquinone of wine-steaming processed Rheum palmatum was significantly lower than the crude one. Meanwhile, the laxative effect was moderate obviously. Initial defecation time of processed group was longer than those of the crude group and model one, grade and rate of loose stools of the processed group was less than the crude group and model group. Maximum tolerance dose was far more than 100 times compared with clinical dose ( 0. 06 g/kg ) in acute toxicity test and no death or poisoning occurred in the mice. Pathological changes were not found in main organs. The best wine-steaming processing technology was as follows:the ratio of crude Rheum palmatum and wine was 1 :7. 5 ( kg/L ) , the stewing time was 1 h, the stewing and heating time was 4 h. Conclusion Reasonable processing of Rheum palmatum based on Mongolian medicine theory can significantly ease laxative effect, eliminate pain and other adverse reactions, reduce toxicity, thereby increase the curative effect of Rheum palmatum, and expand the scope of medicine.关键词
蒙药/大黄/酒焖大黄/炮制工艺/药理/毒理Key words
Mongolian medicine/Rheum palmatum/wine-steaming processed Rheum palmatum/processing technology/pharmacology/toxicology分类
医药卫生引用本文复制引用
苏布达,阿润,那生桑..大黄蒙医酒焖炮制机理及有效性研究[J].中国药业,2017,26(19):19-23,5.基金项目
内蒙古自治区自然科学基金项目[kj15sf22]. （）
