中国药业2017，Vol.26Issue(19)：27-30,4.DOI:10.3969/j.issn.1006-4931.2017.19.007
阿帕替尼对宫颈癌HeLa细胞体外放射作用的研究
Radiate Effect of Apatinib on Human Cervical Carcinoma HeLa Cells in Vitro
摘要
Abstract
Objective To investigate the radiate effect of apatinib ( APA ) on human cervical carcinoma HeLa cells in vitro. Methods HeLa cells with logarithmic phase were divided into radiotherapy group and APA combined radiotherapy group. Proliferation inhibition of HeLa cell from APA was detected by MTT, the radiosensitivity of HeLa cell was observed by clone formation assay. Results Proliferation inhibition of HeLa cell from APA was a concentration- dependent increase. Cell clone number and cell survival fraction of the APA combined radiotherapy group were lower than the radiotherapy group. Sensitization enhancement ratio ( SERD0 ) of APA was 0. 851, SERDq was 14. 919 and SERSF2 was 1. 245. Conclusion APA has the proliferation inhibition role to HeLa cell in vitro, combined with radiotherapy can enhance the synergistic effect of sublethal injury and cell death.关键词
阿帕替尼/宫颈癌/HeLa细胞/放射治疗/放射敏感性Key words
apatinib/cervical cancer/HeLa cell/radiotherapy/radiosensitivity分类
医药卫生引用本文复制引用
刘伟,张建文..阿帕替尼对宫颈癌HeLa细胞体外放射作用的研究[J].中国药业,2017,26(19):27-30,4.基金项目
中国临床肿瘤学科学基金,CSCO-恒瑞肿瘤研究基金项目[Y-HR2016-046]. （）
